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مقالات فارسیISIکنفرانسهاژورنالها

Evaluation of the Total Oxidant Status to the Antioxidant Capacity Ratio as a Valuable Biomarker in Breast Cancer Patients

محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 12، شماره: 2
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 75

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1863467

شناسه ملی سند علمی:

JR_RBMB-12-2_008

تاریخ نمایه سازی: 4 دی 1402

چکیده مقاله:

Background: The oxidative balance is a state of equilibrium between oxidants and antioxidants disrupted in various disorders, including BC. This study aimed to assess this equilibrium in breast cancer (BC) patients by looking at the oxidant-to-antioxidant ratio. Methods: This case-control study comprised ۴۰ women patients with breast cancer and ۳۰ age-matched healthy individuals. The oxidation-reduction colorimetric technique was used to determine serum levels of total oxidant status (TOS) and total antioxidant capacity (TAC). The oxidant-to-antioxidant balance was estimated using the TOS- to- TAC ratio (TOS/TAC). Results: The mean TOS in healthy individuals was ۸.۴۰±۲.۰۶ µmol/L, while in BC patients it was ۱۳.۳۱±۲.۱۶ µmol/L (P< ۰.۰۰۱). The mean serum level of TAC was ۱.۴۳±۰.۲۱ mmol/L in healthy individuals and ۱.۱۹±۰.۱۵ mmol/L in BC patients (P< ۰.۰۰۱). The mean serum TOS/TAC was ۶.۰۱±۰.۳۲ in the healthy individuals and ۱۱.۴۲±۰.۴۱ in the BC patients (P< ۰.۰۰۰۱). There were direct correlations between TAC and estrogen receptor (r=۰.۳۳۹, P=۰.۰۳۸). The TOS/TAC level has a sensitivity of ۱۰۰% and specificity of ۸۳.۳۳%, distinguishing patients with BC from healthy controls (P< ۰.۰۰۱). A significant trend of increasing risk with rising TOS/TAC levels was also seen [OR=۳.۶۲, (۹۵ % CI ۱.۷۹, ۷.۳۵)]. Conclusions: In breast cancer, the serum TOS to TAC ratio can better diagnose oxidative equilibrium than either component alone.

کلیدواژه ها:

Antioxidants ، Biomarkers ، Breast Cancer ، Oxidants ، Oxidative stress.

نویسندگان

Ahmad Ahmadzadeh

Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran.

Mohammad Javad Khodayar

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Maryam Salehcheh

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Zahra Nazari Khorasgani

Nanotechnology Research Center, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mehrnoush Matin

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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