The Effect of Salvia Officinalis Extract on P۵۳ and Creatine Kinase Levels in Downhill Running: A Crossover Randomized, Double-Blind, and Placebo-Controlled Study

The effect of salvia officinalis (Sage) extract on levels of p۵۳ and creatine kinase (CK) after eccentric exercise is unclear.Objective: In the present study, the effect of salvia officinalis extract on serum levels of p۵۳ and CK after a downhill running was investigatedMethods: ۱۴ healthy men (age, ۲۴.۴±۳.۵ yr; body mass index, ۲۲.۴۶±۱.۵ kg/m۲) were randomly placed in two conditions of sage and placebo. Subjects took ۵۰۰ mg capsules of sage extract (two daily) or placebo for two weeks. After ۱۴ days, subjects performed downhill running at ۱۲% downhill grade at about ۷۰% of the maximum heart rate until volitional exhaustion (۳۰ minutes). Blood sampling was performed before and immediately after the running workout for the measurement of the serum p۵۳ and CK concentrations. Results: The results showed that in the sage condition, the changes in p۵۳ levels in the before exercise compared to the after running were not statistically significant (p = ۰.۱۴). In the placebo condition, p۵۳ levels in the post- running increased significantly compared to the pre- running (p = ۰.۰۰۱). Also, CK levels in the post-running only in the placebo condition increased significantly compared to the pre- running (p = ۰.۰۰۷). Conclusion: The findings of the present study showed that downhill running as eccentric contraction may lead to cell apoptosis and muscle damage by increasing p۵۳ and CK levels, but short-term sage supplementation is likely inhibits increased apoptosis and muscle damage marker in serum induced by acute exercise.