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مقالات فارسیISIکنفرانسهاژورنالها

Amplification of Wound Healing by Propolis and Honey Ointment in Healthy and Diabetic Rat Models; Histopathological and Morphometric Findings

محل انتشار: مجله آرشیو رازی، دوره: 77، شماره: 5
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 61

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https://civilica.com/doc/1867547

شناسه ملی سند علمی:

JR_ARCHRAZI-77-5_018

تاریخ نمایه سازی: 6 دی 1402

چکیده مقاله:

Skin wound healing, especially in diabetic patients, has been a major medical challenge for decades. In the meantime, the use of traditional medicine has always been questioned. Propolis) resin and wax (is one of the most likely solutions to this problem. The present study aimed to establish an animal model for healing skin wounds and diabetic ulcers. To this aim, rats were randomly allocated into two healthy and diabetic groups (۵۰ mg/kg streptozotocin resulted in diabetes with high BSL to ۳۰۰ mg/dL), which were divided into four subgroups. The ۷ mm full-thickness skin wounds were created on the abdomen region in ۸۰ male Wistar rats using paunch. In the subgroups, the wounds were cleaned with normal ۰.۹% saline as the control subgroup and dressed with Eucerit, ۱.۵% honey+eucerit, and ۳% propolis +۱.۵% honey+eucerit, once daily for ۱۴ days in other subgroups, respectively. On days ۱, ۳, ۵, and ۷ after the intervention, wound and area contractions were calculated using digital photographs measurement. The histopathological and semi-quantitative studies were performed on days ۷ and ۱۴ after wounds creation. The microscopic findings demonstrated that the granulation tissue, fibroblasts, re-epithelization, and angiogenesis increased (P≤۰.۰۵) in the subgroups treated by propolis and honey combination in healthy and diabetic rats within ۷ and ۱۴ days post-injury. Also, less inflammation and a significant reduction in wound contraction were observed in the same subgroups on days ۳, ۵, and ۷ compared to other subgroups (P≤۰.۰۵). The results indicated that significant healing quality and acceleration were affected by propolis and honey compared to other subgroups on days ۳ and ۵ (P≤۰.۰۵).

کلیدواژه ها:

Animal model ، diabetes ، Honey ، Propolis ، WOUND HEALING

نویسندگان

A. A Salrian

Toxin Research Center, AJA University of Medical Sciences, Tehran, Iran

A Behzadi

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

M. M Oloumi

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran

M Farajli Abbasi

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

S Delshad

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran

M Moghadaszadeh

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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