Immunological Role of Toll-Like Receptor Markers (TLR۲ and TLR۴) in Patients with Helicobacter pylori infection at Basrah, Iraq
محل انتشار: مجله آرشیو رازی، دوره: 78، شماره: 2
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 45
فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ARCHRAZI-78-2_012
تاریخ نمایه سازی: 6 دی 1402
چکیده مقاله:
Helicobacter pylori is a spiral-shaped, flagellated, microaerophilic bacteria found in the human gastric sub-mucosa. This study aimed to investigate the association between toll-like receptor markers (TLR۲ and TLR۴) and the infection with Helicobacter pylori. The study involved ۲۲۴ participants randomly divided into ۲ equal groups (n=۱۱۲). The patient group (n=۱۱۲) was involved with several gastrointestinal symptoms. They were compared to a control group (n=۱۱۲) with negative H. pylori tests. Patients and control were subjected to upper digestive endoscopy with gastric biopsy for the rapid urease test, rapid diagnostic test, and ELISA test for TLR۲ and TLR۴ detection. The recorded data showed that ۳۶ (۳۲.۱ %) patients with H. pylori were in the second to the third decades of their life (۲۵-۳۴ years), while ۲۲ (۱۹.۶ %) positive H. pylori-infected individuals were in the age range of ۱۵-۲۴ years, which were very close to the participants in the age range of ۳۵-۴۴ years. On the other hand, it is revealed that ۱۵ (۱۳.۴%) participants were in the fourth to fifth decades of life. This rate was very similar to the groups of patients within the sixth to seventh decades of their life (۱۳ (۱۱.۶ %)), but the lowest number of cases with H. pylori patients found in the age range of ۵۵-۶۴ years were recorded ۷.۱%. In conclusion, the concentration of TLR۲ and TLR۴ is higher in H. pylori-positive participants compared to the control group. This might reflect the response of innate immunity of the body to the presence of H. pylori infection, and thus it may be used as an ancillary tool in the detection of the patient's susceptibility to this type of infection.
کلیدواژه ها:
نویسندگان
R. A Kareem
Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq
L Kadhim Baqer
Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :