Assessment of Interleukin-۱۳(rs۲۰۵۴۱) Genomic Polymorphism in Patients with Acute Respiratory Distress Syndrome in Relation to COVID۱۹ Infection
محل انتشار: مجله آرشیو رازی، دوره: 77، شماره: 6
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 42
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شناسه ملی سند علمی:
JR_ARCHRAZI-77-6_033
تاریخ نمایه سازی: 6 دی 1402
چکیده مقاله:
Elevated Interleukin-۱۳ (IL-۱۳) may play an important role in the pathophysiology of COVID-۱۹, yet, the attenuated response did not notice across all severe cases. Susceptibility to asthma in specific populations is associated with several SNPs of multifunctional cytokines, such as IL-۱۳, IL-۳۱ and IL-۳۳. This prospective case-control study is designed to investigate the extent of genetic susceptibility in subsets of Iraqi patients with COVID-۱۹ by targeting the variants of interleukin IL-۱۳rs۲۰۵۴۱ polymorphism in relation to disease susceptibility and severity of clinical presentation. One hundred samples were obtained from the throat, nasopharyngeal and nasal swabs enrolled in this study. Eighty samples of the throat, nasopharyngeal and nasal localization swabs were obtained from patients with acute respiratory distress syndrome (ARDS) (both COVID-۱۹ and non-COVID۱۹ patients), while other ۲۰ nasopharyngeal swabs were included as a healthy control group (AHC). Detection of IL-۱۳rs۲۰۵۴۱ polymorphism was done by ARMS technique. The frequencies of GG- genotype in ARDS- patients with COVID-۱۹, non-COVID۱۹-, and AHC groups were respectively ۱۴%, ۱۲% and ۳%, where, and as compared to the control group, showed a significant increase in COVID-۱۹ patients. The AA- genotype in patients with COVID-۱۹ group, non- COVID-۱۹ group and healthy control group documented the frequency of ۹%, ۷%, and ۱۴%, respectively, where the frequency decreased in the patient's groups as compared to the AHC group. Finally, and among the studied groups, an increase of AG- genotype (as rate OR=۱.۸۹) was documented compared to genotype GG and A-. Genetic polymorphisms in the IL-۱۳rs۲۰۵۴۱ gene might influence its functions in patients with SARS-associated respiratory tract infection and thus might involve the pathogenicity of patients with COVID-۱۹.
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نویسندگان
A Modher Nabat Al-Ajrash
Ministry of Health, Imam Sadiq Teaching Hospital, Hillah, Iraq
S. H Mohammed Ali
College of Medicine, University of Baghdad, Baghdad, Iraq
Y. J Al-Bayaa
College of Medicine, University of Baghdad, Baghdad, Iraq
S. H MohammedAl-Alwany
College of Science, University of Babylon, Babylon, Iraq
A. Y Al-Hijazi
Al-Mustaqbal University College, Dentistry Department, Babylon, Iraq
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