Bifidobacteriaceae Family Diversity in Gut Microbiota of Patients with Renal Failure
محل انتشار: مجله آرشیو رازی، دوره: 76، شماره: 3
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 47
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شناسه ملی سند علمی:
JR_ARCHRAZI-76-3_012
تاریخ نمایه سازی: 6 دی 1402
چکیده مقاله:
Bifidobacteriaceae family are gut microbiota that exhibit probiotic or health promoting effects on the host. Several studies have suggested that gut microbiota are quantitatively and qualitatively altered in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). The present study aimed to assess the members of Bifidobacteriaceae family in fecal samples of patients with CKD and ESRD and compare them with non-CKD/ESRD patients to find any changes in their counts and diversions in these patients. Twenty fresh fecal samples from patients with CKD/ESRD and twenty from non-CKD/ESRD patients were examined. Whole DNA was extracted from fecal samples and the gut microbiota composition was analyzed by next generation sequencing (NGS). A total of ۶۵۱ strains were identified from ۴۰ fecal samples, ۸ (۱.۲۳%) strains of which were identified as family Bifidobacteriaceae. The most abundant species in both control and disease groups were Bifidobacterium adolescentis and Bifidobacterium longum subsp. longum, and the least abundant species in the disease group was Bifidobacterium animalis subsp. lactis. There was no significant difference in the abundance of various species between the disease and control groups (p < ۰.۰۵). This study confirms that the members of the Bifidobacteriaceae family are not altered in patients with CKD/ESRD.
کلیدواژه ها:
Bifidobacteriaceae ، Chronic Kidney Disease (CKD) ، End-Stage Renal Disease (ESRD) ، Next Generation Sequencing (NGS)
نویسندگان
Gh. R Hanifi
Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
H Samadi Kafil
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
H Tayebi Khosroshahi
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
R. Shapouri
Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
M Asgharzadeh
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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