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مقالات فارسیISIکنفرانسهاژورنالها

Histopathology and Histomorphological Study of Wound Healing Using Clove Extract Nanofibers (Eugenol) Compared to Zinc Oxide Nanofibers on the Skin of Rats

محل انتشار: مجله آرشیو رازی، دوره: 74، شماره: 3
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 63

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https://civilica.com/doc/1868634

شناسه ملی سند علمی:

JR_ARCHRAZI-74-3_006

تاریخ نمایه سازی: 6 دی 1402

چکیده مقاله:

In order to evaluate the healing effect of eugenol and other nanofibers, ۱۰۰ male Wistar rats (۲۰۰±۱۰ g) were used with ۱۴-۱۵ weeks of age in this study. All of the male rats were transferred in the standard cages under controlled exposure conditions in a ۱۲:۱۲ h light/dark cycle with a constant temperature about ۲۲±۲ oC. In addition, the male rats were fed with pellets. Firstly, anesthesia process was performed by ۲% xylazine hydrochloride (۱۰mg/Kg/IP) and ۱۰% ketamine hydrochloride (۱۰۰mg/Kg/IP), and then the rats were placed on the operating table. Then the dorsal surfaces of the rats’ skin to ileum were scrubbed and prepared as the next step. A circular wound (with a ۷ mm diameter) was created by a ۷ mm sterile biopsy punch. All ۱۰۰ rats were divided into four groups (n=۲۵) randomly named as control, nano zinc oxide (ZnO), eugenol nanofibers, and polycaprolactone groups. After that, they were divided into five groups regarding the wound closure rate in days ۳, ۵, ۷, ۱۴, and ۲۱. Then, the wound dressings were placed on the wounds and renewed every ۲۴ h. At the end of days ۳, ۵, ۷, ۱۴, and ۲۱, the relevant tests, such as histopathology, were conducted by removing the tissue volume using a biopsy punch, and then decapitation process was performed on the rats. It was obvious that eugenol nanofiber showed the best granulation tissue by the production of collagen. Further studies are being performed on wound healing by eugenol nanofiber.

کلیدواژه ها:

Nanofibres ، eugenol ، Zinc oxide ، skin ، rat ، WOUND HEALING

نویسندگان

M. A. Ashjazadeh

Department of Clinical Science, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

A. jahandideh

Department of Clinical Science, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

G. Abedi

Department of Clinical Science, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

A. Akbarzadeh

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

S. Hesaraki

Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran

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