Phenolic Compounds, Antioxidants, and Antibacterial Activity of Some Native Medicinal Plants Against Pseudomonas Aeruginosa
محل انتشار: مجله تحقیقات دارویی و بیومدیک، دوره: 8، شماره: 4
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 52
فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_PBRE-8-4_002
تاریخ نمایه سازی: 10 دی 1402
چکیده مقاله:
Background: Traditional medicines have a wide range of pharmacological properties. Objectives: This work was done to investigate the antimicrobial effect of Thymus vulgaris, Matricaria chamomilla, Melissa officinalis, and Rhus coriaria extracts against clinical isolates of Pseudomonas aeruginosa.
Methods: A total of ۱۸۰ P. aeruginosa clinical isolates were examined. Using the disc diffusion method, MIC and MBC of the methanol and alcohol herbal extracts were measured. Furthermore, microtiter plate assay evaluated biofilm development in the P. aeruginosa isolates. The free radical scavenging activity of the plant extracts against ۲,۲-diphenyl-۱-picrylhydrazyl (DPPH) was determined.
Results: Results showed that P. aeruginosa strains were resistant to more than three different classes of antibiotics. Our results demonstrated that the MBC value of ethanol and methanol extracts of thyme was ۴۳.۷۵ mg/mL, and ۳۱.۲۵ mg/mL, respectively. The highest MIC and MBC values were observed for the thyme and Lemon balm had the lowest MIC and MBC values. Our study showed that thyme extract was the most efficient plant extract against P. aeruginosa. The Mean±SD scavenging activity of thyme, chamomile, sumac, and lemon balm was ۹۱.۰۵±۱.۱۰, ۸۹.۵۵±۰.۷۰, ۶۴.۶۵±۱.۹۵, and ۸۰.۱±۰.۳۰%, respectively
Conclusion: These findings may help in reducing our dependence on antibiotics and handling infections of opportunistic pathogens more efficiently. Further studies are required to distinguish the most important phytochemical compounds and estimate their antibiofilm activities and their mechanisms of action.
کلیدواژه ها:
نویسندگان
Mandana Ahmadi
Department of Microbiology, College of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
Nima Bahador
Department of Microbiology, College of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
Alireza Khodavandi
Department of Biology, College of Sciences, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :