The Pharmacological Activities and Toxicological Effects of Amygdalin: A Review
محل انتشار: مجله تحقیقات دارویی و بیومدیک، دوره: 8، شماره: 1
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 43
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شناسه ملی سند علمی:
JR_PBRE-8-1_001
تاریخ نمایه سازی: 10 دی 1402
چکیده مقاله:
Background: Amygdalin has a wide range of pharmacological activities including analgesic and anti-asthmatic effects. In spite of several studies that have shown the cytotoxic effects of amygdalin on the different cancer cell lines, no general agreement has yet been reached on the anti-cancer aspect of amygdalin.
Objectives: The review aims to focus on the pharmacological activities and toxicological effects of amygdalin and provide a reference and perspective for its further investigation.
Methods: Electronic databases including the Web of Science, PubMed, Google Scholar and sciencedirect were searched up to identify eligible studies about of the pharmacological activities and toxicological effects of amygdalin and provide a reference and perspective for its further investigation. Generally, a total of ۹۰ papers about in vitro/in vivo studies on amygdalin have been reviewed.
Results: Pharmacological activities of amygdalin have been well documented over the years, however, in some cases; dose-dependent toxicity has been reported in the human body. Since the acute toxicity experiments of amygdalin has proved that the toxicity of oral administration route is far greater than the intravenous route. Thus, several in vitro and in vivo studies are needed to assess the amygdalin’s pharmacological value as the induction of apoptosis and anti-cancer drug.
Conclusion: Amygdalin is known to have generally dose-dependent effects with positive or desirable effects at lower doses and undesirable effects generally above this level of intake in some in the treatment of some diseases, although there is substantial inter-individual variation.
کلیدواژه ها:
نویسندگان
Parisa Saberi-Hasanabadi
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Fatemeh Shaki
Department of Pharmacology and Toxicology, School of Pharmacy Pharmaceutical Sciences Research Center Hemoglobinopathy Research Institute Mazandaran University of Medical Sciences
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