Effects of Methanol Extract on Bioactive Property and in Vitro Antioxidant Activity of Palma Christi (Anthocleista nobilis G. Don.) Root

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 37

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شناسه ملی سند علمی:

JR_PBRE-7-4_008

تاریخ نمایه سازی: 10 دی 1402

چکیده مقاله:

Background: Plants have diverse phytochemicals with different solubility levels and medicinal efficacy. This study aimed to determine the presence of phytochemical constituents and in vitro antioxidant activity of methanol root extract of Anthocleista nobilis. Objectives: Determining the bioactive principles and free radical scavenging properties of A. nobilis root. Methods: The preliminary phytochemical investigations were performed using standard analytical procedures. The in vitro antioxidant properties were assessed by ۲,۲-diphenyl-۱-picrylhydrazyl (DPPH) free radical scavenging assay, nitric oxide (NO) scavenging activity, ferric reducing antioxidant power (FRAP) assay, total antioxidant capacity (TAC), and hydrogen peroxide (H۲O۲) scavenging activity. Results: The phytochemical analyses revealed the presence of several compounds: saponins, reducing sugar, alkaloids, tannins, flavonoids, cardiac glycosides, and mucilages. The concentrations of these compounds were different. A considerable quantity of phytochemicals was found in the methanol extract. The impact of the extract on DPPH, NO, FRAP, TAC, H۲O۲ radicals were dependently and ascendingly concentrated. Solvent extract demonstrated better antioxidant activity, with DPPH and NO showing maximum antioxidant capability in conjunction with IC۵۰ values of ۵.۴۵ µg/mL. Conclusion: The study results prove that A. nobilis is a possible source of natural antioxidants, justifying its use in indigenous medicine.

نویسندگان

Adekunle Orimisan Ojatula

Phytomedicine Research Centre, Botany Programme, Department of Biological Sciences, Faculty of Science, Ondo State University of Science and Technology, Okitipupa, Nigeria.

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