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مقالات فارسیISIکنفرانسهاژورنالها

Serum vitamin D levels in girls with central precocious puberty

محل انتشار: مجله تحقیقات دارویی و بیومدیک، دوره: 4، شماره: 1
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 54

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لینک ثابت به این مقاله:
https://civilica.com/doc/1872419

شناسه ملی سند علمی:

JR_PBRE-4-1_003

تاریخ نمایه سازی: 10 دی 1402

چکیده مقاله:

Precocious puberty can cause several adverse effects on final growth and social behavior in girls. Recent studies showed that low serum level of vitamin D might be associated with precocious puberty. The aim of this research was to investigate the association between serum vitamin D level and central precocious puberty in girls. Girls with central precocious puberty under the age of eight were enrolled in the study. Subjects with brain tumor, inherent adrenal hyperplasia, or thyroid dysfunction were excluded from the study. Age, weight, height, serum level of vitamin D, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, free thyroxin (FT۴), bone age, thyroid-stimulating hormone (TSH), and Tanner stages were determined for all the subjects. Healthy girls with no precocious puberty were considered as the control group. Finally, ۵۸ girls (۲۸ with central precocious puberty and ۳۰ healthy) were included in the study. The average levels of serum vitamin D were ۱۲.۹ ± ۷.۸ ng/mL and ۱۵.۲±۵.۹ ng/mL in the case and control groups, respectively (P = ۰.۰۲). We found that ۳۷% of girls with precocious puberty were in Tanner stage ۲ and ۶۳% in stage ۳. The serum vitamin D level had considerable relationship with chronological-bone age difference (P < ۰.۰۱). Vitamin D deficiency was more common in girls with central precocious puberty than those with normal sexual maturation. Insufficiency and deficiency of vitamin D were more common in girls who were evaluated in this study in comparison with other studies.

کلیدواژه ها:

Vitamin D ، precocious puberty ، bone age

نویسندگان

Mohammadreza Rafati

Department of Clinical Pharmacy,Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Daniel Zamanfar

Department of Pediatrics, Diabetes Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Seyedeh-Nesa Rezaeian Shiadeh

School of Pharmacy, Mashhad University of Medical Sciences, Sari, Iran

Fatemeh Faramarzi

Department of Clinical Pharmacy, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

Mohsen Aarabi

Department of Social Medicine, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Hamid Rayati Damavandi

General Practitioner, Astaneh Square, Babol, Iran

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