Serum zinc and copper levels in children with febrile convulsion
محل انتشار: مجله تحقیقات دارویی و بیومدیک، دوره: 2، شماره: 3
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 46
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شناسه ملی سند علمی:
JR_PBRE-2-3_003
تاریخ نمایه سازی: 10 دی 1402
چکیده مقاله:
Febrile convulsions (FC) are the most common neurologic disorder in children ۶-۶۰ months of age. Zinc (Zn) and copper (Cu) play role as cofactors in more than ۳۰۰ enzymatic activities significantly. The aim of this study was to evaluate the relationship serum levels of Zn and Cu with seizure occurrence in febrile children. In this case-control study, ۲۷۰ children with ۶ month to ۶ years were evaluated. The patients were enrolled in three groups: a) children with febrile convulsion, b) febrile children without convulsion and c) healthy ones. After recording of all patients’ characteristics, ۵ mL blood was taken from peripheral vessels at the first ۱۲ hours of hospitalization. Absorption of all samples was read by BRAIC (Rayleigh instrument) company, WFX-۱۳۰ model with calibration diagram, considering samples dilution levels. The mean of serum Zn levels in children with FC were significantly lower than other two groups. Mean serum Cu levels in children with FC and non-FC patients were significantly higher than healthy children. No meaningful differences were observed in serum levels of Zn and Cu among the girl or boy cases. This study showed significant lower serum zinc level in children with febrile seizure and meaningful higher serum copper level than control group cases. There was no significant difference in level of serum zinc and copper in term of sex.
نویسندگان
Mohammad Shokrzadeh
Pharmaceutical Sciences Research Center, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Science, Sari, Iran
Ali Abbaskhaniyan
Department of Pediatrics, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran
Mohammadreza Rafati
Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Science, Sari, Iran
Mahdi Mashhadiakabr
Mazandaran University of Medical Science, Sari, Iran
Ali Arab
Department of Pediatrics, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran
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