Development of lipid micromatrices based sustained release tablets of glipizide: suitability of stearic acid as release retardant
محل انتشار: مجله تحقیقات دارویی و بیومدیک، دوره: 2، شماره: 2
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 39
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شناسه ملی سند علمی:
JR_PBRE-2-2_002
تاریخ نمایه سازی: 10 دی 1402
چکیده مقاله:
The objective of research was to explore the suitability of lipids like compritol ۸۸۸ ATO and stearic acid as release retardant to develop sustained release (SR) tablets. The SR micromatrices of lipid (s) and glipizide were prepared (LM۱- LM۶) as intermediate product by fusion method and assessed for various pharmacotechnical properties. Micromatrices were formulated as SR tablets (F۱-F۶) by direct compression method and subjected to Pharmacopoeial and Non Pharmacopoeial tests. In vitro drug release behavior of SR tablets demonstrated incomplete release of drug from compitrol based formulations whereas stearic acid based formulations (F۴-F۶) released more than ۹۰% drug in ۱۲ h with F۵ displaying maximum %CDR of ۹۵.۷۰ ± ۰.۷۸%. A t۵۰% of ۳ h exhibited by F۵ was significantly lower (۲.۷ h) than of marketed formulation (Glytop SR® (t۵۰% = ۵.۷ h)). Similarity and dissimilarity factor for F۵, with reference to Glytop SR® was ۲۱.۶۵% and ۲۶.۳۴% respectively, suggesting F۵ has potential to exercise better control on drug release. Scanning Electron Microscopy (SEM) revealed drug particles embedded in stearic acid micromatrices that were confirmed by The X-ray powder diffraction (XRPD) and simultaneously Diffuse Reflectance Infrared Fourier Transform (DRIFT) confirmed the stability of F۵. Conclusively, stearic acid explored as a suitable lipidic release retardant for development of SR tablet of glipizide that were stable for the test period of ۶ months.
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نویسندگان
Deepak Singh
Rajiv Academy for Pharmacy, Delhi Mathura Road, P.O. Chhatikara, Mathura-۲۸۱۰۰۱, INDIA
Vijay Sharma
Department of Pharmaceutics, Sri Sai College of Pharmacy, Dalhousie Road, Badhani, Pathankot – ۱۴۵۰۰۱, Punjab, INDIA
Kamla Pathak
Department of Pharmaceutics, Pharmacy College Saifai, UPRIMS & R, Saifai, Etawah -۲۰۶۱۳۰, Uttar Pradesh, INDIA
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