Dabigatran etexilate - A novel oral anticoagulant for bleeding complications

سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 38

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شناسه ملی سند علمی:

JR_PBRE-1-3_001

تاریخ نمایه سازی: 10 دی 1402

چکیده مقاله:

Thromboembolic disease is a common cause of morbidity and mortality. Thrombin plays a key role in thrombotic events and thrombin inhibition represents a therapeutic event for thromboembolic events and has been identified as a target of therapy of its pivotal role in coagulation process. Anticoagulation is a major intervention for the management of arterial and venous thromboembolic events. Dabigatran etexilate is an orally effective anti-thrombin drug, several animal and human trials were conformed the efficacy of this drug in reduction of major bleeding in related to acute coronary syndrome, knee replacement surgery and venous thromboembolism conditions. The therapeutic use of this drug also shows limited side effects to select the dabigatran as promising therapeutic agent in bleeding complications.

نویسندگان

Himabindu Reddy

Department of Pharmacology and Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, India

Chakka Gopinath

Department of Pharmacology and Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, India

Mohamed Saleem Thattakudian Sheikuduman

Department of Pharmacology and Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, India

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