Antioxidant, Anti-inflammatory, and Anticoagulation Properties of Aegiceras corniculatum and Acanthus ilicifolius

Rana Biswas; S. M. Mahbubur Rahman; Kazi Mohammed Didarul Islam; Md. Morsaline Billah; Afiya Aunjum; Tauhidur Rahman Nurunnabi; Sujan Kumar Kundu; Md. Emdadul Islam

Antioxidant, Anti-inflammatory, and Anticoagulation Properties of Aegiceras corniculatum and Acanthus ilicifolius

محل انتشار: مجله تحقیقات دارویی و بیومدیک، دوره: 5، شماره: 3

سال انتشار: 1398

نوع سند: مقاله ژورنالی

زبان: انگلیسی

مشاهده: 46

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لینک ثابت به این مقاله:

https://civilica.com/doc/1872498

شناسه ملی سند علمی:

JR_PBRE-5-3_007

تاریخ نمایه سازی: 10 دی 1402

چکیده مقاله:

Free radical production from different biological and environmental sources is due to an imbalance of natural antioxidants, which further leads to inflammation. Antioxidant metabolites are often characterized by anti-inflammatory and anticoagulation activity. Mangrove plants synthesize different classes of metabolites, including antioxidants, to minimize the devastating effect of oxidation resulting from the elevated salinity, UV, and other unique geochemical components. Accordingly, this study aimed at investigating the antioxidant, anti-inflammatory, and anticoagulation properties, as well as polyphenol content of the two selected mangrove plant species: Aegiceras corniculatum and Acanthus ilicifolius. We used the ۲,۲-diphenyl-۱-picrylhydrazyl (DPPH) assay, reducing power, ferric reducing antioxidant power (FRAP) assay, β-carotene-linoleic acid bleaching assay (BCB), total phenolic content (TPC), total flavonoid content (TFC) and total tannin content (TTC) to determine antioxidant activity of the ethanol extract of A. corniculatum bark and leaves and A. ilicifolius leaves. Furthermore, human red blood cell (HRBC) membrane stabilization assay, lipoxygenase (LOX) inhibition assay, and prothrombin time (PT) test were performed for determining anti-inflammatory activity of the samples. A. corniculatum bark is a potent antioxidant (IC۵۰ ۲۰.۴۹ ± ۲.۱۴ µg/mL in DPPH assay) with anti-inflammatory (IC۵۰ ۲۳.۵۸ ± ۱.۷۵ µg/mL in LOX inhibition assay) and anticoagulation activity (۱۸.۱۹ ± ۰.۱۳ min in prothrombin time assay) compared to other extracts. All extracts were found with significant (P<۰.۰۰۱) antioxidant, anti-inflammatory, and anticoagulation properties. Further studies on liquid chromatography-mass spectrometry (LC-MS) analysis, anti-inflammatory, and anticoagulation are recommended.

کلیدواژه ها:

Antioxidant ، Anti-inflammatory ، Anticoagulation ، Mangrove ، Sundarbans

نویسندگان

Rana Biswas