ورود
مقالات فارسیISIکنفرانسهاژورنالها

Encapsulation of nystatin in nanoliposomal formulation: characterization, stability study and antifungal activity against Candida albicans

محل انتشار: مجله تحقیقات دارویی و بیومدیک، دوره: 2، شماره: 1
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 49

فایل این مقاله در 11 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1872537

شناسه ملی سند علمی:

JR_PBRE-2-1_006

تاریخ نمایه سازی: 10 دی 1402

چکیده مقاله:

In this study, nystatin liposomal formulation was prepared and characterized. The physicochemical properties of formulations including vesicle size, drug entrapment stability and in vitro release were studied. The highest entrapment efficiency of nystatin into liposomes was obtained about ۷۰% when cholesterol (CHO) was added to the formulations prepared with dipalmitoylphosphatidylcholine. In addition, the drug entrapment efficiency was decreased when distearoylphosphatidylcholine was used   but it was improved by addition of CHO and hydration   with ۹% sucrose solution. Liposomes with uniform size distribution and average size of ۱۰۰ nm were produced.  Long term stability study indicated that the lyophilized liposomal nystatin was physically stable for at least ۶ months at ۴ °C. In vitro anti-fungal activity of liposomal nystatin was found to be more effective than free nystatin against Candida albicans.

کلیدواژه ها:

Liposome ، lyophilization ، antifungal activity ، nystatin ، nanotechnology

نویسندگان

Ebrahim Saadat

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Rassoul Dinarvand

Medical Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, Iran

Pedram Ebrahimnejad

Departmentof Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Pons V, Greenspan D, Lozada NF, McPhail L, Gallant JE, ...
  • Arikan S, Ostrosky-Zeichner L, Lozano-Chiu M, Paetznick V, Gordon D, ...
  • Stanley VC, English MP. Some effects of nystatin on the ...
  • Elizabeth MJ, Joshua OO, Adrien S, Thomas LW and David ...
  • Akaike N, Harata N. Nystatin perforated patch recording and its ...
  • Coutinho A, Prieto M. Cooperative partition model of nystatin interaction ...
  • Schafer KM, Blechschmidt J, Korting HC. Clinical use of oral ...
  • Moribe K, Maruyama K, Iwatsuru M. Encapsulation characteristics of nystatin ...
  • Newcomer VD, Wright ET, Sternberg TH, Graham JH, Wier RH ...
  • Drummond DC, Meyer O, Hong K, Kirpotin DB and Papahadjopoulos ...
  • Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. ...
  • Chen C, Han D, Cai C, Tang X. An overview ...
  • Sharma A, Sharma US. Liposomes in drug delivery: progress and ...
  • Balasubramanian SV, Straubinger RM. Taxol-lipid interactions: taxol dependent effects on ...
  • Zhang JA, Xuan T, Parmar M, Ma L, Ugwu S, ...
  • Kunikazu MK, Motoharu I. Spectroscopic investigation of the molecular state ...
  • Mehta RT, Hopfer RL, Gunner LA, Juliano RL, and Lopez-Berestein ...
  • Wallace TL, Paetznick V, Cossum PA, Lopez-Berenstein G, Rex JH ...
  • Mehta RT, Hopfer RL, McQueen T, Juliano RL, and Lopez-Berestein ...
  • Dirk H, Petra R and Ann O. Protection of liposomes ...
  • Thomas DM, Marcel BB, Michael JH, Pieter RC, Hugh PS ...
  • Maitani Y, Aso Y, Yamada A, Yoshioka S. Effect of ...
  • Molina MC, Allison SD, Anchordoquy TJ. Maintenance of nonviral vector ...
  • Anchordoquy TJ, Carpenter JF, and Kroll DJ. Maintenance of transfection ...
  • Li B, Li S, Tan Y, Stolz DB, Watkins SC, ...
  • Molina MC, Armstrong TK, Zhang Y, Patel MM, Lentz YK ...
    • نمایش کامل مراجع