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مقالات فارسیISIکنفرانسهاژورنالها

Association of digoxin with mortality and rehospitalization in heart failure patients treated with beta-blockers: Results from the Persian Heart Failure Patient Registry

محل انتشار: مجله آریا آترواسکلروز، دوره: 18، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 50

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لینک ثابت به این مقاله:
https://civilica.com/doc/1873036

شناسه ملی سند علمی:

JR_RYA-18-3_009

تاریخ نمایه سازی: 11 دی 1402

چکیده مقاله:

BACKGROUND: Numerous clinical trials have reported conflicting results regarding the benefit of digoxin in treating heart failure (HF) patients. This study was conducted with the aim to demonstrate the impact of added digoxin to beta-blocker and beta-blocker alone on all-cause mortality and rehospitalization among these patients.METHODS: We investigated the data of ۱۹۹۸ patients admitted with a primary diagnosis of decompensated HF in the prospective Persian Heart Failure Patients Registry in Iran. The outcomes of interest were time until death and time until first rehospitalization. Multivariate cox regression was used to compare the impact of beta-blocker plus digoxin and beta-blocker alone on ۲.۵-year survival and ۹۰-day rehospitalization.RESULTS: The mean age of the participants was ۶۹.۱۸ ± ۱۳.۲۶ years, and ۳۸.۱% of patients were women. The incidence rate of all-cause mortality in the total sample was ۰.۱۸ and ۰.۲۲ in patients on beta-blocker plus digoxin and beta-blocker alone, respectively [incidence rate ratio (IRR) = ۱.۲۵; ۹۵% CI: ۰.۹۲-۱.۷]. The adjusted risk of all-cause mortality was significantly higher in women discharged with beta-blocker plus digoxin than beta-blocker groups [hazard ratio (HR) = ۲.۳۱; ۹۵% CI: ۱.۲۷-۴.۱۹]. Rates of ۹۰-day first rehospitalization were ۰.۱۰ and ۰.۱۲ in the beta-blocker plus digoxin and beta-blocker alone groups, respectively (IRR = ۰.۸۵; ۹۵% CI: ۰.۵۳-۱.۳۵). After adjustment for covariates, beta-blocker plus digoxin therapy had no significant effect on increasing the risk of ۹۰-day first rehospitalization in the total cohort (HR = ۰.۷۷; ۹۵% CI: ۰.۴۸-۱.۲۳), in men (HR = ۰.۷۳; ۹۵% CI: ۰.۴۰-۱.۳۵), and women (HR = ۰.۷۶; ۹۵% CI: ۰.۳۶-۱.۶۵).CONCLUSION: In patients hospitalized with decompensated HF, digoxin administration at discharge was associated with increased ۳۰-month mortality risk in women.

کلیدواژه ها:

Adrenergic beta-Antagonists ، Digoxin ، Heart Failure ، Hospitalization ، Mortality

نویسندگان

Maryam Yazdi

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Davood Shafie

Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Mahshid Givi

Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammad Garakyaraghi

Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isahan, Iran

Nizal Sarrafzadegan

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Ghasem Yadegarfar

Heart Failure Research Center, Cardiovascular Research Institute, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran AND University of Central Lancashire, Preston, UK

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