ورود
مقالات فارسیISIکنفرانسهاژورنالها

Expression levels of miR-۲۲, miR-۳۰c, miR-۱۴۵, and miR-۵۱۹d and their possible associations with inflammatory markers among patients with coronary artery disease

محل انتشار: مجله آریا آترواسکلروز، دوره: 18، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 58

فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1873037

شناسه ملی سند علمی:

JR_RYA-18-3_010

تاریخ نمایه سازی: 11 دی 1402

چکیده مقاله:

BACKGROUND: Coronary artery disease (CAD) is a leading cause of death around the world. Micro-ribonucleic acid (miRNA) can be involved in forming of atherosclerotic plaques, inflammation, cholesterol metabolism, and other mechanisms involved in CAD development. This study aimed to evaluate the expression level of miR-۲۲, miR-۳۰c, miR-۱۴۵, and miR-۵۱۹d and their possible association with inflammatory markers among patients with CAD.METHODS: The expression level of miR-۲۲, miR-۳۰c, miR-۱۴۵, miR-۵۱۹d, interleukin ۶ (IL-۶), and transforming growth factor beta (TGF-β) was determined in peripheral blood mononuclear cells (PBMCs) from ۴۶ patients with CAD and ۳۹ healthy controls using real-time quantitative polymerase chain reaction (qPCR) assay.RESULTS: ۵۳.۸% (n = ۲۱) and ۵۲.۲% (n = ۲۴) of controls and cases were men, respectively; the mean age was ۵۹.۸ ± ۷.۴ and ۵۷.۰ ± ۹.۸ years, respectively. The miRNA expression pattern of each group showed significantly different expression profiles. In the CAD patients group, miR-۲۲, miR-۳۰c, and miR-۱۴۵ were down-regulated compared to the control group. On the opposite, miR-۵۱۹d was up-regulated in patients with CAD compared to the control group. Our results also showed that the expression levels of IL-۶ and TGF-β were up-regulated among patients with CAD compared to the control group. In addition, the expression of miR-۱۴۵ and miR-۵۱۹d had a significantly negative and positive correlation with TGF-β and IL-۶, respectively.CONCLUSION: The change in expression levels of miR-۲۲, miR-۳۰c, miR-۱۴۵, and miR-۵۱۹d in PBMCs of patients with CAD could be considered as a potential biomarker for CAD.

کلیدواژه ها:

Coronary Artery Diseases ، miRNAs ، Peripheral blood mononuclear cell

نویسندگان

Saied Ghorbani

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Seyed Hashem Sezavar

Department of Cardiology, School of Medicine AND Research Center for Prevention of Cardiovascular Endocrinology and Metabolism, Research Institute Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran

Farah Bokharaei-Salim

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Angila Ataei-Pirkooh

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Ahmad Tavakoli

Department of Virology, School of Medicine AND Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

Davod Javanmard

Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran

Javid Sadri-Nahand

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Seyed Jalal Kiani

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Hadi Ghaffari

Department of Bacteriology and Virology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Leila Beikzadeh

Department of Medical Laboratory Sciences, School of Paramedicine, Alborz University of Medical Sciences, Karaj, Iran

Latif Hamidpoor

Iranian Blood Transfusion Organization, Tehran, Iran

Seyed Hamidreza Monavari

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Fazmin IT, Achercouk Z, Edling CE, Said A, Jeevaratnam K. ...
  • GBD ۲۰۱۵ Disease and Injury Incidence and Prevalence Collaborators. Global, ...
  • GBD ۲۰۱۵ Mortality and Causes of Death Collaborators. Global, regional, ...
  • Chen LJ, Lim SH, Yeh YT, Lien SC, Chiu JJ. ...
  • Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl ...
  • Gimbrone MA, Garcia-Cardena G. Endothelial cell dysfunction and the pathobiology ...
  • Thakore AH, Guo CY, Larson MG, Corey D, Wang TJ, ...
  • Campos H, Genest JJ, Blijlevens E, McNamara JR, Jenner JL, ...
  • Saadati S, Eskandari V, Rahmani F, Mahmoudi MJ, Rahnemoon Z, ...
  • Bai Y, Zhang P, Zhang X, Huang J, Hu S, ...
  • Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, ...
  • Keshavarz M, Dianat-Moghadam H, Sofiani VH, Karimzadeh M, Zargar M, ...
  • Satoh M, Takahashi Y, Tabuchi T, Tamada M, Takahashi K, ...
  • Kadam P, Bhalerao S. Sample size calculation. Int J Ayurveda ...
  • Chen KC, Juo SH. MicroRNAs in atherosclerosis. Kaohsiung J Med ...
  • Flowers E, Froelicher ES, Aouizerat BE. MicroRNA regulation of lipid ...
  • Guo X, Li D, Chen M, Chen L, Zhang B, ...
  • Wang D, Atanasov AG. The microRNAs regulating vascular smooth muscle ...
  • Essandoh K, Li Y, Huo J, Fan GC. MiRNA-mediated macrophage ...
  • Moore KJ, Rayner KJ, Suarez Y, Fernandez-Hernando C. The role ...
  • Bidzhekov K, Gan L, Denecke B, Rostalsky A, Hristov M, ...
  • Zhang Y, Zhang L, Wang Y, Ding H, Xue S, ...
  • Melak T, Baynes HW. Circulating microRNAs as possible biomarkers for ...
  • Roifman I, Beck PL, Anderson TJ, Eisenberg MJ, Genest J. ...
  • Ling B, Wang GX, Long G, Qiu JH, Hu ZL. ...
  • Yang QY, Yang KP, Li ZZ. MiR-۲۲ restrains proliferation of ...
  • Huang WQ, Wei P, Lin RQ, Huang F. Protective effects ...
  • Anderson DR, Poterucha JT, Mikuls TR, Duryee MJ, Garvin RP, ...
  • Chen B, Luo L, Zhu W, Wei X, Li S, ...
  • Soh J, Iqbal J, Queiroz J, Fernandez-Hernando C, Hussain MM. ...
  • Gatling AM. The Role of MicroRNA-۳۰C in Regulating Plasma Lipids ...
  • AIM-HIGH Investigators. The role of niacin in raising high-density lipoprotein ...
  • Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, ...
  • Ceolotto G, Giannella A, Albiero M, Kuppusamy M, Radu C, ...
  • Zhao W, Zhao SP, Zhao YH. MicroRNA-۱۴۳/-۱۴۵ in cardiovascular diseases. ...
  • Zhao N, Koenig SN, Trask AJ, Lin CH, Hans CP, ...
  • Wang W, Chen L, Shang C, Jin Z, Yao F, ...
  • He M, Wu N, Leong MC, Zhang W, Ye Z, ...
  • Faccini J, Ruidavets JB, Cordelier P, Martins F, Maoret JJ, ...
  • Martinelli R, Nardelli C, Pilone V, Buonomo T, Liguori R, ...
  • Joseph AT, Bhardwaj SK, Srivastava LK. Role of prefrontal cortex ...
  • Chu C, Liu X, Bai X, Zhao T, Wang M, ...
  • Gu W, Zhan H, Zhou XY, Yao L, Yan M, ...
  • Xia Y, Chen Q, Zhong Z, Xu C, Wu C, ...
  • Hua M, Qin Y, Sheng M, Cui X, Chen W, ...
  • Chen R, Zhou S, Chen J, Lin S, Ye F, ...
  • Lee JS, Ko EJ, Hwang HS, Lee YN, Kwon YM, ...
    • نمایش کامل مراجع