A randomized, Double-blind Clinical Trial of the Three-month Effect of Garlic Administration on Cardiac Outcomes in Patients with Heart Failure

Sima Azish; Mohammad Garakyaraghi; Mehrbod Vakhshoori; Maryam Heidarpour; Mohaddeseh Behjati; Kiyan Heshmat-Ghahdarijani; Sepehr Omoomi; Mohammad Fakhrolmobasheri; Davood Shafie; Nizal Sarrafzadegan

A randomized, Double-blind Clinical Trial of the Three-month Effect of Garlic Administration on Cardiac Outcomes in Patients with Heart Failure

محل انتشار: مجله آریا آترواسکلروز، دوره: 18، شماره: 6

سال انتشار: 1401

نوع سند: مقاله ژورنالی

زبان: انگلیسی

مشاهده: 53

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https://civilica.com/doc/1873044

شناسه ملی سند علمی:

JR_RYA-18-6_010

تاریخ نمایه سازی: 11 دی 1402

چکیده مقاله:

BACKGROUND: Garlic may have anti-oxidanmayti-hypertensive and anti-hyperlipidemic properties. However, the effects of its administration on cardiac function in heart failure (HF) patients impact require further investigation. We aimed to evaluate garlic prescription effects on cardiac outcomes and quality of life scores in Iranian HF patients.METHODS: From August to December ۲۰۲۰, a randomized, double-blind clinical trial was conducted. Individuals with heart failure (New York heart association (NYHA) functional class of II and III) referred to private clinics in Isfahan, Iran, were randomly assigned to intervention (n=۸۰) and control (n=۸۰) groups. They have received ۵۰۰ mg of odorless garlic tablets or the same shape and dosage of placebo twice daily for three months. Laboratory data, cardiac outcomes (end-diastolic diameter, ventricular septal thickness, NYHA functional class, left ventricular ejection fraction), quality of life score (Minnesota living with HF questionnaire), and the Modified Borg Scale (MBS) were all evaluated at the baseline and the end of the trial.RESULTS: The population’s mean age was ۵۸.۱±۱۳.۵ years (۵۵% males). Patients who consumed garlic had remarkably improved functional class compared to placebo takers and their baseline (NYHA practical class of II, ۷۹.۴% vs. ۵۰.۶%, P<۰.۰۰۱ and ۷۹.۴% vs. ۵۴%, P=۰.۰۰۶, respectively). MBS levels were significantly lower among garlic consumers (baseline: ۲.۵۲±۰.۵, after three months: ۲.۲±۱.۰۶, P= ۰.۰۴۰).CONCLUSIONS: Garlic administration may improve cardiac function and breathe in HF patients. Complementary research is necessary to confirm our findings.

کلیدواژه ها:

Heart Failure ، Garlic ، Randomized Controlled Trial ، Quality of Life

نویسندگان

Sima Azish

Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammad Garakyaraghi