Comparison of the anti-inflammatory and antilipidemic activity of diosmin and saroglitazar in a model of nonalcoholic fatty liver induced by a high-fat diet in Wistar rats

Reza Afarin; Negar Dinarvand; Bahar Jaberian Asl; Ghazal Orak; Elham Shakerian; Fatemeh Bineshfar; Akram Ahangarpour

Comparison of the anti-inflammatory and antilipidemic activity of diosmin and saroglitazar in a model of nonalcoholic fatty liver induced by a high-fat diet in Wistar rats

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 27، شماره: 2

سال انتشار: 1403

نوع سند: مقاله ژورنالی

زبان: انگلیسی

مشاهده: 45

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https://civilica.com/doc/1877424

شناسه ملی سند علمی:

JR_IJBMS-27-2_014

تاریخ نمایه سازی: 16 دی 1402

چکیده مقاله:

Objective(s): Non-alcoholic fatty liver disease (NAFLD) is the most common liver-related metabolic disorder in the world, with a global prevalence of ۲۵%. Compounds with anti-inflammatory, lipid-lowering, and insulin-sensitizing properties can be used for the prevention or treatment of NAFLD. Therefore, this study was conducted to investigate the effect of saroglitazar (a dual PPARα/γ agonist) and diosmin (a flavonoid) on non-alcoholic fatty liver induced by a high-fat diet (HFD) in Wistar rats.Materials and Methods: Forty male Wistar rats (۶–۸ weeks old) were fed an HFD to induce NAFLD. After ۷ weeks, rats were divided into four groups: group۱ was fed HFD, and the other groups received HFD+saroglitazar, HFD+diosmin, and HFD+ saroglitazar+diosmin. We examined body and liver weight, histopathology, serum levels of liver enzymes (ALT and AST), and lipid profiles (LDL-C and HDL-C) using the standard protocols. qRT-PCR was also used to examine the expression of PPARα, PPARγ, SREBP۱c, FAS, ACC, CPT۱α, and pro-inflammatory genes (IL۶, TNFα, and TGFβ). Results: Rats fed the HFD showed characteristics of NAFLD (pathologically and biochemically). Administration of saroglitazar and diosmin alone caused a significant decrease in the levels of PPARγ, SREBP۱c, FAS, ACC, ALT, AST, LDL-C, and pro-inflammatory genes and a significant increase in PPARα, CPT۱a, and HDL-C in comparison with the HF group (P<۰.۰۵). Their combined effect was more evident. Conclusion: Our results showed that diosmin, like saroglitazar, significantly ameliorated inflammatory and lipid profiles in HFD-induced NAFLD, suggesting that diosmin, as a natural compound, could be a suitable alternative to saroglitazar.

کلیدواژه ها:

Diosmin ، Non-alcoholic fatty liver disease ، Non-alcoholic steatohepatitis ، Saroglitazar ، TGFβ

نویسندگان

Reza Afarin