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مقالات فارسیISIکنفرانسهاژورنالها

Fabrication and evaluation of the regenerative effect of a polycaprolactone/chitosan nanofibrous scaffold containing bentonite nanoparticles in a rat model of deep second-degree burn injury

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 27، شماره: 2
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 62

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1877426

شناسه ملی سند علمی:

JR_IJBMS-27-2_012

تاریخ نمایه سازی: 16 دی 1402

چکیده مقاله:

Objective(s): In the present study, we evaluated the effect of a nanofibrous scaffold including polycaprolactone (PCL), chitosan (CHT), and bentonite nanoparticles (Ben-NPS) on wound healing in order to introduce a novel dressing for burn wounds. Materials and Methods: PCL, PCL/CHT, and PCL/CHT/Ben-NPS nanofibrous scaffolds were fabricated by the electrospinning technique. Their structural and physiochemical characteristics were investigated by Fourier-transform infrared spectroscopy (FTIR) analysis, scanning electron microscopy (SEM), tensile strength, water contact angle, as well as, swelling and degradation profiles test. The disc diffusion assay was carried out to investigate the antibacterial potential of the scaffolds. In addition, the cell viability and proliferation ability of human dermal fibroblasts (HDFs) on the scaffolds were assessed using MTT assay as well as SEM imaging. The wound-healing property of the nanofibrous scaffolds was evaluated by histopathological investigations during ۳,۷, and ۱۴ days in a rat model of burn wounds. Results: SEM showed that all scaffolds had three-dimensional, beadles-integrated structures. Adding Ben-NPS into the PCL/CHT polymeric composite significantly enhanced the mechanical, swelling, and antibacterial properties. HDFs had the most cell viability and proliferation values on the PCL/CHT/Ben-NPS scaffold. Histopathological evaluation in the rat model revealed that dressing animal wounds with the PCL/CHT/Ben-NPS scaffold promotes wound healing. Conclusion: The PCL/CHT/Ben-NPS scaffold has promising regenerative properties for accelerating skin wound healing.

کلیدواژه ها:

Bentonite-nanoparticles ، Nanofibrous scaffold ، Polycaprolactone ، Rat ، Wound healing

نویسندگان

Seyedeh Sara Hashemi

Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Ali-Akbar Mohammadi

Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Mehdi Kian

Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

Alireza Rafati

Division of Pharmacology and Pharmaceutical Chemistry, Sarvestan Branch, Islamic Azad University, Sarvestan, Fars, Iran

Mojtaba Ghaedi

Department of Surgery, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Fars, Iran

Behzad Ghafari

Division of Plastic and Reconstructive Surgery, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

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