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Pharmacokinetic enhancement of marbofloxacin by alpha-۱-monolaurin pre-treatment in broiler chickens

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 15، شماره: 1
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 62

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لینک ثابت به این مقاله:
https://civilica.com/doc/1883964

شناسه ملی سند علمی:

JR_VRFAN-15-1_001

تاریخ نمایه سازی: 25 دی 1402

چکیده مقاله:

The present study investigated the prospect of improvement in pharmacokinetic (PK) parameters of marbofloxacin due to alpha-۱-monolaurin pre-treatment in broiler chickens. Two groups of broilers were administered a single oral dose of marbofloxacin (۵.۰۰ mg kg-۱ body weight): Group-I without pre-treatment and Group-II with alpha-۱-monolaurin pre-treatment (۴.۰۰ g kg-۱ feed for ۱۰ days). Blood sampling was done periodically for both groups and plasma marbofloxacin concentrations were determined using ultra-high performance liquid chromatography. Pharmacokinetic parameters using non-compartmental modelling approach were calculated with the PKSolver software. Statistical analysis revealed significant differences in plasma marbofloxacin concentrations between the two groups at ۱, ۲, and ۲۴ hr. Group-II birds exhibited a higher mean maximum plasma concentration (۲.۴۳ µg mL-۱) at an earlier time (Tmax: ۱.۳۸ hr) compared to Group-I. The plasma concentrations of marbofloxacin were maintained above ۰.۱۰ and ۰.۱۸ µg mL-۱ up to ۲۴ hr in Group-I and Group-II broilers, respectively. Significant differences were observed in PK parameters such as the area under the curve and total body clearance. The mean relative oral bioavailability of Group-II birds compared to Group-I was ۱۱۹.۶۱%. The findings of the study provided evidence of PK parameters enhancement of marbofloxacin in the alpha-۱-monolaurin pre-treated group. The calculated PK-pharmacodynamic indices for marbofloxacin predicted clinical efficaciousness in the broiler chickens.

کلیدواژه ها:

Alpha-۱-monolaurin ، Broiler chickens ، Marbofloxacin ، Oral pharmacokinetics

نویسندگان

Sheen Tukra

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar, India

Ratn Singh

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar, India

Hiteshkumar Patel

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar, India

Vaidehi Sarvaiya

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar, India

Sanjaykumar Vaghela

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar, India

Ankitkumar Patel

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar, India

Shaileshkumar Mody

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagar, India

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