Radioprotective Effects of Sulfur-containing Mineral Water of Ramsar Hot Spring with High Natural Background Radiation on Mouse Bone Marrow Cells
محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 7، شماره: 4
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 42
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شناسه ملی سند علمی:
JR_JBPE-7-4_004
تاریخ نمایه سازی: 30 دی 1402
چکیده مقاله:
Background: We intend to study the inhibitory effect of sulfur compound in Ramsar hot spring mineral on tumor-genesis ability of high natural background radiation. Objective: The radioprotective effect of sulfur compounds was previously shown on radiation-induced chromosomal aberration, micronuclei in mouse bone marrow cells and human peripheral lymphocyte. Ramsar is known for having the highest level of natural background radiation on Earth. This study was performed to show the radioprotective effect of sulfur-containing Ramsar mineral water on mouse bone marrow cells. Methods: Mice were fed three types of water (drinking water, Ramsar radioactive water containing sulfur and Ramsar radioactive water whose sulfur was removed). Ten days after feeding, mice were irradiated by gamma rays (۰, ۲ and ۴ Gy). ۴۸ and ۷۲ hours after irradiating, mice were killed and femurs were removed. Frequency of micronuclei was determined in bone marrow erythrocytes. Results: A significant reduction was shown in the rate of micronuclei polychromatic erythrocyte in sulfur-containing hot spring water compared to sulfur-free water in hot spring mineral water. Gamma irradiation induced significant increases in micronuclei polychromatic erythrocyte (MNPCE) and decreases in polychromatic erythrocyte/polychromatic erythrocyte + normochromatic erythrocyte ratio (PCEs/PCEs+NCEs) (P < ۰.۰۰۱) in sulfur-containing hot spring water compared to sulfur-free hot spring mineral water. Also, apparently there was a significant difference between drinking water and sulfur-containing hot spring water in micronuclei polychromatic erythrocyte and polychromatic erythrocyte/polychromatic erythrocyte+ normochromatic erythrocyte ratio. Conclusion: The results indicate that sulfur-containing mineral water could result in a significant reduction in radiation-induced micronuclei representing the radioprotective effect of sulfur compounds.
کلیدواژه ها:
High Natural Background Radiation (HNBR) ، Sulfur ، Gamma rays ، Bone Marrow Micronucleus Assay ، Ramsar
نویسندگان
A H Heidari
Department of Biophysics and Biochemistry, Faculty of Medical Sciences, Babol Medical University, Babol, Iran
A Shabestani Monfared
Department of Biophysics and Biochemistry, Faculty of Medical Sciences, Babol Medical University, Babol, Iran
H Mozdarani
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
A Mahmoudzadeh
Novin Medical Radiation Institute, Tehran, Iran
A Razzaghdoust
Department of Radiology, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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