In-vitro Study of Photothermal Anticancer Activity of Carboxylated Multiwalled Carbon Nanotubes
محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 7، شماره: 4
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 45
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شناسه ملی سند علمی:
JR_JBPE-7-4_002
تاریخ نمایه سازی: 30 دی 1402
چکیده مقاله:
Background and Objective: Multi-walled Carbon Nano Tubes (MWCNTs) as an important element of nanosciences have a remarkable absorption in the region of NIR window (۶۵۰-۹۰۰ nm) which can overcome the limitations of deep treatment in photothermal therapy. To disperse MWCNTs in water, it is proposed to attach carboxylated functional group (-COOH) to MWCNTs in order to increase dispersivity in water.Materials and Methods: A stable suspension of MWCNTs-COOH with different concentrations (from ۲.۵ to ۵۰۰ μg/ml) was prepared. Then, they were compared for their ability to increase temperature in the presence of ۸۱۰ nm laser irradiation and through a wide range of radiation time (from ۲۰ to ۶۰۰ s) and three laser powers (۱.۵, ۲ and ۲.۵ w). The temperature rise was recorded real time every ۲۰ seconds by a precise thermometer.Results: Absorption spectrum of MWCNTs-COOH suspension was remarkably higher than water in a wavelength range of ۲۰۰ to ۱۱۰۰ nm. For example, using the concentrations of ۲.۵ and ۸۰ μg/ml of MWCNTs-COOH suspension caused a temperature elevation ۲.۳۵ and ۹.۲۳ times compared to water, respectively, upon ۱۰ min laser irradiation and ۲.۵ w. Moreover, this predominance can be observed for ۱.۵ and ۲ w radiation powers, too. Our findings show that the maximum of temperature increase was obtained at ۸۰ μg/ml concentration of MWCNT-COOH suspension for three powers and through all periods of exposure time. Our results show that the minimum required parameters for a ۵°C temperature increase (a ۵°C temperature increase causes cell death) were achieved through ۲.۵ w, ۲۸ μg/ml concentration and ۲۰ second irradiation time in which both concentration and radiation times were relatively low.Conclusion: Our results showed that MWCNTs-COOH can be considered as a potent photothermal agent in targeted therapies. New strategies must be developed to minimize the concentration, irradiation time and radiation power used in experiments.
کلیدواژه ها:
نویسندگان
M H Bahreyni-Toosi
Medical Physics Research Center, Medical Physics Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
M H Zare
Medical Physics Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
A Ale davood
Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
M T Shakeri
Department of Community Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
S Soudmand
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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