Evaluation of Diffusion Anisotropy and Diffusion Shape in Grading of Glial Tumors

Background: The most common primary tumors of brain are gliomas. Grading of tumor is vital for designing proper treatment plans. The gold standard choice to determine the grade of glial tumor is biopsy which is an invasive method.Objective: In this study, we try to investigate the role of fractional anisotropy (diffusion anisotropy) and linear anisotropy coefficient (its shape) with the aim of Diffusion Tensor imaging (as a non-invasive method) in the grading of gliomas.Methods: A group of ۲۰ patients with histologically glial approved was evaluated. In this study, we used a ۱.۵-Tesla MR system (AVANTO; Siemens, Germany) with a standard head coil for scanning. Multi-directional diffusion weighted imaging (measured in ۱۲ non-collinear directions) and T۱ weighted non-enhanced were performed for all patients. We defined two Regions of Interest (ROIs); white matter adjacent to the tumor and the homologous fiber tracts to the first ROI in the contralateral hemisphere.Results: Linear anisotropy coefficient (CL), fractional anisotropy (FA) values and ratios of low-grade peri-tumoral fiber tracts were higher than high-grade gliomas (P-value CLt=۰.۰۱۴, P-value CLt/n=۰.۰۱۹ and P-value FAt=۰.۰۰۶, P-value FAt/n=۰.۰۲۴). In addition, we perform ROC curve for each parameter (CL ratio-AUC = ۰.۸۲ and FA ratio-AUC = ۰.۸۶۸).Conclusion: Our findings prove significant difference between diffusion anisotropy (FA) and diffusion shape (Cl) between low grade and high grade glioma, based on which we find this evaluation helpful in the grading of glial tumors.