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مقالات فارسیISIکنفرانسهاژورنالها

Radioprotective Effect of Rosmarinus officinalis L (Rosemary) Essential Oil on Apoptosis, Necrosis and Mitotic Death of Human Peripheral Lymphocytes (PBMCs)

محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 12، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 42

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1892648

شناسه ملی سند علمی:

JR_JBPE-12-3_004

تاریخ نمایه سازی: 30 دی 1402

چکیده مقاله:

Background: Rosemary plant, with phenolic compounds, is known as an antioxidant herb and able to scavenge free radical agents in the biological environment; therefore, it is expected that the rosemary essential oil (R-EO) shows the radioprotective effect to protect individuals who are physically in contact with ionizing radiation. Objective: This study aimed to assess the radioprotective effect of R-EO on human peripheral blood mononuclear cells (PBMCs).Material and Methods: In this experimental study, the toxicity of the rosemary essential oil on PBMCs was assessed by the ۳-(۴, ۵-dimethylthiazolyl-۲)-۲, ۵-diphenyltetrazolium bromide (MTT) assay. The cells were irradiated at ۰. ۲۵ and ۲۰۰ cGy using a ۶ MV X-ray linear accelerator. The survival, apoptosis, necrosis, and survival enhancement factors of cells were analyzed by MTT and flow cytometry analyses with a non-toxic concentration of the rosemary essential oil (IC۱۰). Results: Irradiation of cells in the presence of R-EO caused a significant increase in cell survival compared with the control in both ۲۵ and ۲۰۰ cGy radiation doses. Also, the percentages of apoptosis and necrosis of cells showed a significant decrease compared with the control. Conclusion: Rosemary essential oil as a natural and non-toxic compound could show favorable radioprotective effects in such a way that significantly increases the survival rate and decreases the percentage of apoptosis and necrosis of PBMCs.

کلیدواژه ها:

Ionizing radiation ، Radioprotective Agent ، Rosemary Plant ، Apoptosis and Necrosis ، Peripheral Lymphocyte

نویسندگان

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MSc, Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

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PhD, Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

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PhD, Department of Immunology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

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PhD Candidate, Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

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PhD, Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

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