Synthesis of Polymer Nanofibers Containing Mountain Cypress Extract with Antibacterial Properties to Cover Wounds and Produce Chitosan / Polyethylene Oxide Scaffolds Containing Henna Extract in the Industrial Sector to Produce Dressings to Treat Skin Infections

Introduction: Today, finding new antibiotic compounds with minimal side effects is needed. On the other hand, the resistance of bacteria to antibiotics has become a serious problem in the medical world. The aim of this research is the synthesis of polymer nanofibers containing ۱% mountain cypress extract, with antibacterial properties to cover wounds and the production of chitosan/polyethylene oxide scaffolds containing ۱% henna extract in the industrial sector for the production of dressings for the treatment of skin infections.Methods: In this study, in order to investigate the antimicrobial effects of the methanolic extract of mountain cypress plant on standard microbial strains common in skin infection, using MIC, MBC, disking and welling methods, the antibacterial properties of the herbal extract were proved.Results: The results showed that the diameter of the halo of non-growth in the polymer nanofibers containing the synthesized extract on the round coverslip was similar to the polymer solution containing the extract before electrospinning in the bacterial culture medium. Also, the diameter of the halo of non-growth in the disking method for Staphylococcus aureus and Pseudomonas aeruginosa, containing ۳۰۰ micrograms/ml of mountain cypress extract, shows the most accurate value of the control. In Proteus mirabilis bacteria, the welling method with a concentration of ۳۰۰ mg/ml extract was closer to the control. In Escherichia coli and Proteus vulgaris bacteria, the behavior of ۴۸% polymeric nanofiber round lamellar extract was closer to the control (gentamicin disk). In Staphylococcus epidermidis bacteria, the blank disk method of polymer nanofiber ۴۸% extract shows the most accurate value compared to other methods compared to gentamicin. Discussion: According to the results, it seems that the chitosan/polyethylene oxide scaffold containing ۱% henna extract is suitable as a wound cover and facilitates the wound healing process.