A Systematic Review of the Efficacy, Safety, and Satisfaction of Regenerative Medicine Treatments for Hypertrophic Scars and Keloids

What is already known about this topic?• Hypertrophic and keloid scars are unpleasant consequences of skin injuries that pose challenges for doctors and patients when it comes to treatment.• Several treatments, including lasers, intralesional injections of corticosteroids, surgery, intralesional injections of ۵-FU, cryosurgery, and radiotherapy, have been proposed for the treatment of these lesions. Different treatment responses have been observed.• Regenerative medicine plays a pivotal role in treating various skin diseases and post-injury conditions. Examples of these treatment methods include stromal vascular fraction (SVF), stem cell-conditioned medium, cell therapy, platelet-rich plasma (PRP), and exosomes.What does this study add?• In all eight reviewed studies (۱۰۰%), the effectiveness of regenerative medicine in treating hypertrophic and keloid scars has been proven. Out of these eight studies, five (۶۲.۵%) are related to the effectiveness of PRP, two studies (۲۵%) is related to the effectiveness of SVF, and one study (۱۲.۵%) is related to stem cell-conditioned medium.• The use of this treatment method, either as monotherapy (۵۰% of studies) or as an addition to standard treatments (۵۰% of studies), leads to a significant difference in recovery.• In all eight studies (۱۰۰%), the recovery rate in the group treated with regenerative medicine was significantly higher than the group receiving standard treatments such as intralesional injection of triamcinolone acetonide or laser ablation. In one study (۱۶.۶%), regenerative medicine, specifically intralesional injection of PRP, demonstrated superiority over intralesional verapamil injection and intralesional ۵-FU in terms of recovery rate, side effects, and recurrence of lesions.• Regenerative medicine is an effective and safe method for treating hypertrophic scars and keloids. Numerous studies have demonstrated its significant superiority over other treatment methods. Additionally, this treatment method can be combined with conventional therapies, such as laser therapy and intralesional injections