Epigenetic Aspects of Photobiomodulation in Wound Repair

Proliferation forms a vital facet of wound repair, as keratinocytes adjacent to the wound margin divide to provide a sufficient number for the processes of migration and epiboly. Highlights the concept of wound healing, an intricate biological process that involves multiple cellular and molecular interactions to restore tissue integrity. Wound healing is of utmost importance for tissue restoration and is critical to the recovery process following an injury. Any disruption in this process can lead to the development of chronic wounds, which can lead to significant health complications. Emerging evidence indicates the clinical benefits of photobiomodulation therapy (PBMT) in the management of skin and mucosal wounds. Epigenetic Regulators modulate keratinocyte proliferation, migration, and differentiation during skin healing. Epigenetic mechanisms are also vital for keratinocyte differentiation and stratification of the epidermis, differentiation, and migration, while also influencing skin regeneration and new vessel formation. This is achieved through a complex series of regulatory mechanisms that have the ability to both stimulate and inhibit gene activation to transiently alter cell phenotype and behavior as well as interact with factor activity. Understanding the molecular basis of this regulation is a priority as it represents potential therapeutic targets in the treatment of acute and chronic skin conditions. Here, we aim to present aspects of Photobiomodulation therapy drives massive epigenetic histone modifications, stem cells mobilization and accelerated epithelial healing.