Effect of Hydroalcoholic Extract of Solanum Melongena on Mast Cell Numbers and Degranulation in Diabetic Rat Wound Healing

Objective: Many studies have revealed the prominent effects of mast cells in wound healing. In the present study, we assessed the probable therapeutic features of Solanum melongena hydroalcoholic extract on mast cell degranulation in experimental diabetic rats.Method: Skin wounds were generated and treatments were applied with Solanum melongena hydroalcoholic extract intraperitoneally in the sham, control and experimental groups, respectively. Animals were euthanised on days ۳,۵,۷ and۱۵. ۱۶.۸۰۰ microscopic images used to count the mast cells and degranulation level (stereology test, Image J software).Results: Time-lapse photography revealed that Solanum melongena significantly (p<۰.۰۵) increased the total number of mast cells in all experimental groups on days ۵ and ۷. The count of grade III (degranulated) mast cells was reduced significantly (p<۰.۰۵) on days ۵ and ۷ in experimental groups.Conclusion: The rate of wound healing was accelerated considerably following Solanum melongena hydroalcoholic extract administration.