An Overview of the Challenges of Using Stem Cells in Wound Healing

Introduction: Wound complaints are one of the major problems in patients, which can have adverse effects on the aesthetic, functional, psychological and social dimensions of patients. Stem cells with a high tendency to absorb damaged tissues and the proliferation and maturation of undifferentiated cells have led to the healing of burn wounds (peptic ulcer and subsequent cardiovascular disease, diabetic wounds, pressure ulcers and scars caused by wounds. However, this method is still not one of the main approaches in wound healing. This article was compiled with the aim of the challenges in wound healing by stem cells.method: The current research was conducted using a systematic review method in seven steps. First, the topic was selected and ۱۰۶۹ articles were obtained from the databases using the keywords stem cells, wound, healing, challenges and the time limit of the last ۵ years. Then, by determining the entry criteria (abstract and full-text articles, persian and English) and the exit criteria (unrelated and repetitive articles), ۲۱ articles were obtained. After reading the articles, findings were extracted and conclusions were made.Findings: The surveys showed that the existing challenges are in ۶ general categories. On the one hand, the special characteristics of stem cells such as the tumorigenic power, difficult extraction, its sensitivity due to wounds, on the other hand, the individual characteristics of the patient, such as a history of cancer and a history of donation, are some of the limitations. The difficult conditions of cultivation and preparation of products containing stem cells, followed by factors related to transportation, unwanted consequences of adjuvant treatments (surgeries and immunosuppressive drugs), unknown long-term biological, immunological, anatomical and genetic side effects, legal-ethical obstacles and irreversibility of treatment, is another disadvantage of this method.Conclusion: In general, the novelty of the treatment method, the lack of extensive trials and the stated challenges have made the decision to use this method difficult. It is hoped that with more research by researchers, an effective step will be taken in promoting this method