Effects of Silybum Marianum Oil in Nanostructured Lipid Carrier (NLC) on Skin Wound Healing

Silymarin, a flavonoid from Silybum marianum, has been reported to have anti-inflammatory and antioxidant properties. Thus, it may be useful to study the effect of Silybum marianum oil (SM) on wound healing. On the other hand, nanostructured lipid carrier (NLC) is a useful delivery system for essential oil loading and combination of NLC and SM could be a potential candidate for the treatment of skin wounds. Cytotoxicity effect of SM-NLC and SM on HFF-۲ cell line was determined by MTT assay. Cell migration assay was determined by scratch test on HFF-۲ cell line. Our results showed that SM-NLC and SM prompted cell proliferation and migration capability in ۲۴ and ۴۸ hours. The results suggest that SM-NLC could be a potential source for promoting skin wound healing.