Background: Since wound and its treatment, especially surgical wounds, are an important issue, we are trying to provide methods that have less side effects in addition to quick and effective treatment. From the past until now, herbal extracts have been used to heal wounds and they had effects on wound healing due to their properties. This has made researchers to have a special look at herbs and their effect on tissue and wound healing. Achillea Millefolium and Matricaria Recutita herbal extracts have anti-inflammatory and antioxidant effects and have been used as wound healers since ancient times. The purpose of this study is to investigate the histopathological effects of two herbal extracts,
Achillea Millefolium L. and Matricaria Recutita L., and their synergistic effects on wound healing caused by gastrotomy surgery of female rat.Materials and Methods: In this study, ۵۵ adult albino Wistar female rats were randomly divided into ۵ groups of ۱۱. First, a sample of hydroalcoholic extract of the plant was prepared by maceration method. All rats were subjected to gastrotomy surgery. The first group or control group received irrigation with the same amount as other groups of normal saline. The second, third, fourth and fifth groups as treatment groups, respectively, received ۵۰۰ mg/kg Achillea extract, ۲۰۰ mg/kg Matricaria extract and combination of both extracts with the mentioned dose and ۲۰ mg/kg of omeprazole. The extracts, omeprazole and normal saline was given orally by Gavage every ۲۴ hours for ۱۴ days. Thereafter, on days ۳, ۷ and ۱۴ the extent of wound healing was evaluated.Results: Amount of vascularization, fibroblast cell and the percentage of organization of collagen fibers in combination of Achillea Millefolium and Matricaria Recutita treatment group were significantly higher than control group in ۷th and ۱۴th day, and the size of the remaining gap in the wound opening was significantly lower than the control group.Discussion: The combination of
Achillea Millefolium L. and
Matricaria Recutita L. extracts with a positive synergistic effects result in better wound healing of surgical wounds caused by gastrotomy surgery and it can be used as effective as
Omeprazole. each of the two extracts had an inflammatory effect on gastric surgical wounds by their own but their combination and synergistic effect together had a better performance.