The Effects of Betulin on Wound Healing

Introduction: Wound healing is a complex process that involves a series of organized cellular and biochemical events aimed at restoring the integrity and functionality of damaged tissues. Despite the existing treatments, researchers are looking to find natural compounds that may enhance the healing process. Betulin is a triterpenoid compound derived from the bark of various tree species, including birch trees. It has various therapeutic properties including anti-inflammatory, antioxidant, and anti-cancer activities. In this article, we explored the effects of betulin on wound healing.Method: In this study, we searched reliable scientific databases from ۲۰۱۹ to ۲۰۲۳ for the keywords betulin, wound treatment, and wound healing.Result: Betulin promotes re-epithelialization, which involves the migration and proliferation of epithelial cells to cover the wound area. Chronic inflammation and increased oxidative stress often impede the wound-healing process. Betulin has anti-inflammatory properties by suppressing the production of inflammatory mediators, such as prostaglandins and cytokines. Additionally, its antioxidant properties neutralize free radicals, thereby protecting cells from oxidative damage and promoting optimal wound healing. Enough blood supply is important for wound healing, as it supplies necessary nutrients and oxygen to the site of injury. Betulin stimulates angiogenesis, by activating various growth factors and signaling pathways. This improved blood circulation enables tissue regeneration and speeds up the healing process. Collagen, the chief structural protein in the extracellular matrix, plays an important role in wound healing. Betulin has been shown to enhance collagen synthesis, which promotes proper wound closing. In addition, it reduces the formation of scars through the regulation of collagen regeneration and its organized alignment. The significant effects of betulin on wound healing make it a hopeful candidate for various applications in the field of medicine. Further research is necessary to determine the optimal dosage and potential synergistic effects with other wound healing agents.Conclusion: Betulin enhances the natural healing process by reducing inflammation, accelerating wound closure, promoting angiogenesis, and stimulating collagen synthesis. So it has significant potential as a natural compound for improving wound healing