Effect of Cloves Plant on Skin Wound Healing

Background: Skin ulcers are one of the most important and common skin disorders that can decrease the quality of a patient's life. Wound healing is a dynamic process with several stages including homeostasis, inflammation, cell proliferation, and tissue remodeling. If the wound is not treated correctly, it may lead to loss of organs or even death. So far, various treatment methods have been offered in this field. Clove plants have a lot of phenolic compounds, especially eugenol, which has antioxidant, anti-inflammatory, antifungal, antimicrobial, and wound - healing properties. Therefore, in this study, we reviewed the effects of cloves on the healing of skin wounds.Methods: The keywords clove, eugenol, wound healing, and wound treatment in reliable scientific databases such as PubMed, Google Scholar, Scopus, etc. were searched (۲۰۱۹-۲۰۲۳).Result: Clove extract has anti-inflammatory properties and reduces swelling and pain caused by wounds. It also increases effective growth factors in the wound-healing process and promotes angiogenesis in the damaged area. In addition, it stimulates the growth of fibroblasts, which increases collagen production. Clove essential oil shortens the wound-healing process by increasing contraction and reducing the wound epithelialization period.Conclusion: Studies have proven that cloves can improve wound healing. Therefore, it can be used as an effective and innovative method to treat skin wounds.