Effect of Chromolaena Odorata Leaf Extract on Wound Healing

Introduction: Wound and its treatment are an important issue in human life and there are different drugs with various effects for that. One of the appropriate treatments with fewer side effects is the use of medicinal plants which prompted researchers to search for these. One of these plants is Chromolaena odorata. This research aims to investigate the effect of Chromolaena odorata leaf extract on wound healing.Methods: Some terms including “Chromolaena odorata”, “Siam weed” and “wound healing” were searched in PubMed and Google Scholar in recent years to provide an up to date review.Results: Studies showed that Chromolaena odorata Leaf Extract contains a mixture of powerful antioxidant compounds Including phenolic acids, complex mixtures of lipophilic flavonoid aglycones, etc. These compounds enhance conserving the fibroblast and keratinocyte proliferation on wounds and thus wound healing. In addition, they protect cultured skin cells against oxidative damage. This plant has anti inflammatory and antimicrobial properties. Its phytochemical components are alkaloids, flavonoids, flavanone, essential oils, phenolics, saponins, tannins, quercetin, terpenoids, eupolin, quercetagetin, and chromomoric acid which all contribute to its healing properties. The results showed that the use of the appropriate concentration of plant leaf extract in the wound causes blood clotting and reduces the bleeding. also, it was received that heme oxygenase-۱ (HO-۱), the accelerating wound healing enzyme, was increased at the transcriptional and translational levels. In addition, this plant accelerated hemostatic and wound healing activities by altering the expression of genes, including HO-۱, TXS, and MMP-۹.Conclusion: In summary, the obtained results show that Chromolaena odorata leaf extract can be one of effective herbal medicines for healing and treating wounds.