Valine Consumption And Endurance Exercise Modified The Inflammation In Rat Model Of Anxiety/Depression.
محل انتشار: مجله فیزیولوژی و عملکرد ورزش، دوره: 1، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 48
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شناسه ملی سند علمی:
JR_EPP-1-1_008
تاریخ نمایه سازی: 3 بهمن 1402
چکیده مقاله:
Background: Depression and anxiety are disabling conditions with side effects on cognition, quality of life, memory, and mood. Anxiety is a dysregulated mood condition that could disturb cognition. The present study aimed to evaluate the effect of dietary interventions and endurance training in managing anxiety and depressive symptoms.Methods: In this study, ۳۰ rats were divided into five groups: Normal group, anxiety/ depression group, rat model of anxiety/depression who consumed valine ۳.۰ μmol/۵۰۰ μl intraperitoneal injection once/day for eight weeks, rat model of anxiety/depression who conducted endurance training (۳۲ m/min for ۴۵ minutes/session, six days a week for eight weeks), and rat model of anxiety/depression who conducted endurance training (۷۵% VO۲max) and consumed valine (۳.۰ μmol/۵۰۰ μl). The level of anxiety/depression was evaluated by behavior open field tests and relative expression assay of the genes related to the inflammation.Results: Findings indicated that the expression level of the NF-κB and TNFα significantly increased in the anxiety/depression group. Moreover, the endurance training and consumed valine improved the NF-κB and TNFα expression in the brain of the rat model of anxiety/depression. In addition, endurance training and consuming valine decreased the anxiety/depression level.Conclusion: Endurance training and consuming valine reduced the brain's inflammation level and improved the anxiety/depression level.
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نویسندگان
Mohammad-Hossein Beigi
Silicon Hall: Micro/Nano Manufacturing Facility, Faculty of Engineering and Applied Science, Ontario Tech University, Ontario, Canada.