Evaluation of acarbose and metformin on physiological parameters in diabetic male rat induced by high supplementation of fructose

Background: Dietary modification is a frequent strategy used in scientific investigations to replicate circumstances related with insulin resistance, obesity, and type ۲ diabetes.   Objective: This research intended to find out how a high-fructose diet affected glycemic control, antioxidant status, as well as immunological function in male rats. Materials and methods: A group of twenty-four male adult rats was divided at random to four even groups, each composed of six animals. The groupings were categorized as the following: The Negative Control Group comprised rats that received a standard saline. Rats in the Positive Control Group were given solution of a high-fructose (۶۰%) in their drinking water. The rats in the third group received ۳۰ (mg/kg) of acarbose via oral administration. The rats in the fourth group were given ۱۵ mg/kg of metformin orally. Blood samples were taken at the end of the month-long trial to analyze a diverse factors associated with glycemic control and antioxidant status. Results: The results revealed a rise in the glycemic index, Characterized by raised levels of insulin and glucose in the high-fructose treatment group as compared to the control group. However, acarbose treatment has resulted in significant enhancements in glucose regulation, antioxidant status. Conclusion: This study provides a comprehensive analysis of the hyperglycemic effects of fructose and implies that the oral administration of acarbose may serve as a significant intervention to alleviate these effects.