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مقالات فارسیISIکنفرانسهاژورنالها

Possible protective effect of Zataria multiflora Boiss. on salivary glands in patients with differentiated thyroid carcinoma treated with radioiodine: A randomized, double-blind, placebo-controlled clinical trial

محل انتشار: مجله پزشکی هسته ای ایران، دوره: 32، شماره: 1
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 58

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لینک ثابت به این مقاله:
https://civilica.com/doc/1897353

شناسه ملی سند علمی:

JR_IRJNM-32-1_004

تاریخ نمایه سازی: 8 بهمن 1402

چکیده مقاله:

Introduction: The standard treatment for differentiated thyroid carcinoma is post-surgical radioiodine ablation; however, salivary gland damage is prevalent. This study aimed to evaluate the efficacy of Zataria multiflora Boiss. (ZM) aerial part essential oil in protecting salivary glands from post-radioiodine therapy damage in differentiated thyroid cancer patients.Methods: In this randomized clinical trial, ۲۴ patients with differentiated thyroid cancer were randomly allocated to two groups: ۱۱ patients in the ZM essential oil group and ۱۳ in the placebo group. Patients in the intervention and placebo groups received ۲۰ oral drops three times a day of ZM essential oil or placebo respectively, starting from one week before radioiodine therapy to ۴ weeks afterward. Salivary gland function was assessed using scintigraphic parameters before and six months following radioiodine therapy.Results: Follow-up scintigraphy demonstrated significant decrease in parotid UI in the placebo group (P=۰.۰۳۲) while significant increase in UI (P=۰.۰۲۵) and EF (P=۰.۰۴۲) of the parotid was observed in the ZM group. Comparing changes in functional indices of salivary glands between the two groups after six months revealed significantly better function in parotid UI (P=۰.۰۰۵) and parotid EF (P=۰.۰۰۶) in the ZM group. Substantial damage to parotid UI was significantly less in the ZM group (P=۰.۰۴۴).Conclusion: Results of this study demonstrated that administration of ZM essential oil to patients with differentiated thyroid cancer may protect the salivary glands from radioiodine injury.

کلیدواژه ها:

Persian medicine ، Radioiodine ، Salivary gland scintigraphy ، Thyroid cancer ، Zataria multiflora Boiss

نویسندگان

Farinaz Farhoudi

Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Ebrahim Zohalinezhad

Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Mehdi Zarshenas

Department of Phytopharmaceuticals (Traditional Pharmacy), Shiraz University of Medical Sciences, Shiraz, Iran

Nahid Masoudi

Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Ebrahim Fallahzadeh Abarghooei

Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mahdi Haghighatafshar

Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

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