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مقالات فارسیISIکنفرانسهاژورنالها

Insights on the Anti-inflammatory Mechanism of the Polyphenolic-Rich Fraction of Glyphaea brevis (Spreng.) Monachino (Tiliaceae) Leaves

محل انتشار: مجله گیاهان دارویی و محصولات فرعی، دوره: 13، شماره: 1
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 52

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لینک ثابت به این مقاله:
https://civilica.com/doc/1897705

شناسه ملی سند علمی:

JR_JJMPB-13-1_023

تاریخ نمایه سازی: 8 بهمن 1402

چکیده مقاله:

Glyphaea brevis (Spreng.) Monachino has been employed folklorically in West Africa for decades to manage inflammatory disorders such as peptic ulcer, edema, dyspepsia, and worm infestations; however, these pharmacological activities have not been scientifically proven. The study investigated the chemical composition and in-vitro/in-vivo anti-inflammatory capabilities of the polyphenolic-rich fraction of G. brevis leaves (PREG). In-vitro anti-inflammatory indices were evaluated using the human red blood cell (HRBC) methods. The acute lethality (LD۵۰) test was demonstrated in mice with graded dosages (۱۰ to ۵۰۰۰ mg/kg body weight of PREG) via oral intubation. While in-vivo anti-inflammatory activity was determined using a mice model inflicted with an intraperitoneal injection of ۰.۱ml of undiluted fresh egg albumin paw edema using egg albumin. All parameters were assayed according to standard protocols. High levels of tannins, phenols, flavonoids, and minimum amounts of terpenoids, steroids, alkaloids, and saponins were observed in PREG. The LD۵۰ test demonstrated no toxicity and mortality in mice up to ۵.۰ g/kg bw p.o. PREG. The anti-inflammatory assays showed that at the different concentrations (۰.۲ - ۱.۰ mg/ml), PREG effectively inhibited albumin denaturation, platelet aggregation, hypotonicity-induced hemolysis, protease, and phospholipase A۲ activity, as the standard drugs (Aspirin and Prednisolone). Also, PREG suppressed significantly (p< ۰.۰۵) the progression of egg albumin-induced mice paw edema, and these increased with time (۰.۵ - ۵h). The maximum percentage of edema inhibition (۹۱.۴%) was observed in mice administered with ۴۰۰ mg/kg bw PREG, and this was close to that (۹۴.۴۹%) obtained in the group administered with the reference drug (Indomethacin). These give insights into the anti-inflammatory potential of PREG.

کلیدواژه ها:

Glyphaea brevis ، Phytochemicals ، Anti-inflammation ، Albumin Denaturation

نویسندگان

Chukwuma Enechi

Department of Chemical Sciences (Biochemistry Program), Godfrey Okoye University, Enugu State, Nigeria.

Uchenna Abonyi

Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State ۴۱۰۰۰۱, Nigeria

Emmanuel Okeke

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State ۴۱۰۰۰۱, Nigeria Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, Enugu State ۴۱۰۰۰۱, Nigeria Natural Science

Goodness Aker

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State ۴۱۰۰۰۱, Nigeria

Nnamdi Eze

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State ۴۱۰۰۰۱, Nigeria

Chisom Edeh

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State ۴۱۰۰۰۱, Nigeria

Veronica Iloh

Deparment of Pharmaceutical Microbiology & Biotechnology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State ۴۱۰۰۰۱, Nigeria

Stephen Emencheta

Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka

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  • Yang T., Hu Y., Yan Y., Zhou W., Chen G., ...
  • Waghole R.J., Misar A.V., Kulkarni N.S., Khan F., Naik D.G., ...
  • Schauss A.G. Polyphenols and Inflammation. In: Watson RR and Preedy ...
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