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مقالات فارسیISIکنفرانسهاژورنالها

The Effect of Pentoxifylline on the Prevention of Ards in Picu Patients: A Randomized Double-Blind Clinical Trial

محل انتشار: مجله بین المللی کودکان، دوره: 12، شماره: 1
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 60

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لینک ثابت به این مقاله:
https://civilica.com/doc/1901168

شناسه ملی سند علمی:

JR_INJPM-12-1_007

تاریخ نمایه سازی: 14 بهمن 1402

چکیده مقاله:

Background: Inflammation has a remarkable role in Acute Respiratory Distress Syndrome (ARDS) pathophysiology. Pentoxifylline is a phosphodiesterase IV inhibitor with anti-inflammatory and anti-thrombotic properties, which has had positive results in rodents with ARDS. Due to the lack of human studies, we designed this clinical trial to evaluate the pentoxifylline effect on ARDS prevention in high-risk pediatric patients. Methods: We included thirty-four children from Akbar hospital’s pediatric intensive care unit (PICU). These patients were highly susceptible to ARDS progression. Using a randomized, double-blind method, ۱۷ patients received pentoxifylline tablets three times a day for a week, while others received placebo tablets at the same interval for seven days. Lung Injury Prediction Score (LIPS), vital signs, pulse oximetry, PaO۲, pH, and PaCO۲ were measured at baseline and every day for a week period. CRP was assessed at baseline, then on the third and seventh days. Finally, we imported all the data to SPSS software to compare the treatment and placebo groups. Results: Each placebo and treatment group had seventeen patients who had no statistically significant difference in baseline demographic information or lab data. The variations in LIPS score (P=۰.۴۷۵), CRP (P=۰.۰۵۳), pH (P=۰.۱۹۹), PO۲ (P=۰.۰۷۷), PCO۲ (P=۰.۵۲۸), Heart rate (P=۰.۰۸۶), Respiratory rate (P=۰.۵۱۲), Diastolic blood pressure (P=۰.۵۷۲), Systolic blood pressure (P=۰.۵۱۷), and SPO۲ (P=۰.۲۶۰) were compared between the two groups; and no significant difference was observed. Conclusion: The results of this clinical trial suggest that pentoxifylline had no prophylactic effect on pediatric ARDS, but for confirmation, further clinical trials with different designs and larger sample sizes are required.

کلیدواژه ها:

ARDS ، ، ، ، ، Pentoxifylline ، ، ، ، ، Pediatric ICU ، ، ، ، ، RCT

نویسندگان

seyedeh Sahar Nazemi

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran

Vahid Jomezadeh

Department of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Gholamreza Khademi

Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Sara Rahsepar

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran

Ghodsieh Hajzadeh

Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Maryam Naseri

Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mahdiyeh Bahramizadeh

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran

Farshad Abedi

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran

Majid Sezavar

Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

AmirHoushang Mohamadpour

Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

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