ورود
مقالات فارسیISIکنفرانسهاژورنالها

Bone Mineral Density in Patients with Phenylketonuria in Iran

محل انتشار: مجله بین المللی کودکان، دوره: 12، شماره: 1
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 66

فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1901172

شناسه ملی سند علمی:

JR_INJPM-12-1_003

تاریخ نمایه سازی: 14 بهمن 1402

چکیده مقاله:

Background: Factors like low-protein diet may impose Phenylketonuria (PKU) patients to impaired skeletal disease. The present study assessed the status of Bone Mineral Density (BMD) among PKU patients on a low-protein diet. Methods: A cross-sectional study was conducted (Tehran, Iran, ۲۰۱۹). Patients aged ≥ ۴ years old with a definite diagnosis of PKU on a low-protein diet were included. BMD values of the lumbar spine and femoral neck were assessed. The primary objective was assessing femoral and lumbar BMD status in PKU patients. Results: Forty-one PKU patients entered the study. The mean BMI was ۲۰.۷۱۲±۴.۸۳۳ Kg/m۲. The mean bone age was significantly lower than chronological age (۱۰.۹ vs. ۱۲.۴ years; P=۰.۰۰۸). The results showed a bone mass reduction in ۲۳.۱% of all patients.  A significant correlation was observed between lumbar and femoral BMD values (P=۰.۰۰۱; r=۰.۵۱۶). Most patients (about ۷۷%) had lumbar Z-scores>-۱ and ۱۰.۳% showed Z-scores in the range of osteoporosis. Age (P=۰.۰۰۴) and age at diagnosis (P=۰.۰۰۲) were the influencing factors on BMD status. The results showed a significantly inverse correlation between BMD lumbar levels with the patient’s chronological age (P=۰.۰۱۶), age of PKU diagnosis (P=۰.۰۰۲), and phenylalanine level (P=۰.۰۲۵) Conclusion: The results delineated impaired skeletal status among PKU patients on a low-protein diet. Lumbar Z-score values inversely correlated with the patient’s chronological age, age at PKU diagnosis, and phenylalanine level. Hence, early PKU diagnosis and treatment during neonatal period, as well as controlling phenylalanine concentration may improve BMD status.

کلیدواژه ها:

PKU ، BMD ، Phenylketonuria ، Osteopenia ، Osteoporosis

نویسندگان

Aria Setoodeh

Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Samaneh Onsori

Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Parastoo Rostami

Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Ali Rabbani

Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Farzaneh Abbasi

Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Fatemeh Sayarifard

Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Reza Tavakolizadeh

Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran. Maternal, Fetal & Neonatal Research Center, Family Health

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • van Spronsen FJ, Blau N, Harding C, Burlina A, Longo ...
  • Morawska A, Mitchell AE, Etel E, Kirby G, McGill J, ...
  • Etemad K, Heidari A, Setoodeh A, Shayeganrad A, Akhlaghi A, ...
  • de Castro MJ, de Lamas C, Sánchez-Pintos P, González-Lamuño D, ...
  • Demirdas S, van Spronsen FJ, Hollak CE, van der Lee ...
  • Rovelli V, Ercoli V, Dionigi AR, Paci S, Salvatici E, ...
  • Tansek MZ, Bertoncel A, Sebez B, Zibert J, Groselj U, ...
  • Dobrowolski SF, Tourkova IL, Robinson LJ, Secunda C, Spridik K, ...
  • Hansen KE, Ney D. A systematic review of bone mineral ...
  • Mojibi N, Ghazanfari-Sarabi S, Hashemi-Soteh SMB. The Prevalence and incidence ...
  • Ajami N, Soleimani A, Jafarzadeh‐Esfehani R, Hasanpour M, Rashid Shomali ...
  • Kanufre VC, Soares RD, Alves MRA, Aguiar MJ, Starling ALP, ...
  • Tolboom N, Cats E, Helders P, Pruijs J, Engelbert R. ...
  • Modan-Moses D, Vered I, Schwartz G, Anikster Y, Abraham S, ...
  • Pourfarzam M, Zadhoush F. Newborn screening for inherited metabolic disorders; ...
  • Fewtrell M. Bone densitometry in children assessed by dual x-ray ...
  • Aggarwal A, Northrup H, Rodriguez-Buritica DF, Hashmi SS, Saavedra H. ...
  • Coakley KE, Douglas TD, Goodman M, Ramakrishnan U, Dobrowolski SF, ...
  • Barat P, Barthe N, Redonnet-Vernhet I, Parrot F. The impact ...
  • Demirdas S, Coakley KE, Bisschop PH, Hollak CE, Bosch AM, ...
  • Lubout CM, Arrieta Blanco F, Bartosiewicz K, Feillet F, Gizewska ...
  • Ashe K, Kelso W, Farrand S, Panetta J, Fazio T, ...
  • de Groot MJ, Hoeksma M, van Rijn M, Slart RH, ...
  • Barta AG. Phenylketonuria in adulthood: exploring long-term consequences ...
  • Porta F, Mussa A, Zanin A, Greggio NA, Burlina A, ...
  • Adamczyk P, Morawiec-Knysak A, Płudowski P, Banaszak B, Karpe J, ...
  • Stroup BM, Hansen KE, Krueger D, Binkley N, Ney DM. ...
  • Clark EM, Ness AR, Bishop NJ, Tobias JH. Association between ...
  • Heidari A, Arab M, Damari B. A policy analysis of ...
  • Davarani ER, Takaloo FM, Daneshi S, Sanjari P, Khanjani N, ...
    • نمایش کامل مراجع