Electrochemical Determination of Amitriptyline using a Nanocomposite Carbon Paste Electrode in Human Body Fluids

A carbon nanocomposite electrode has been designed by incorporation of montmorillonite nanoclayinto the carbon ionic liquid electrode for the electrochemical determination of amitriptiline . The surface ofthe proposed electrode was characterized by scanning electron microscopy. The presence of ionic liquid asa binder is believed to be responsible for the electrocatalytic activity of the proposed electrode for oxidationof amitriptyline. Low detection limit of ۲۴ nM for amitriptyline was achieved. High stability and reproducibilityas well as the ease of preparation, low cost and surface renewal made this electrode ideal for thedetermination of amitriptyline in human body fluids.