The Effect of Interval Training on Cardiac Angiogenesis Capacity in Rats with Myocardial Infarction
محل انتشار: مجله گزارش بهداشت و درمان، دوره: 5، شماره: 1
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 58
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شناسه ملی سند علمی:
JR_RHCA-5-1_002
تاریخ نمایه سازی: 24 بهمن 1402
چکیده مقاله:
Introduction: Myocardial infarction (MI) is the destruction and permanent and irreversible cell death of part of the cardiac muscle (myocardium) which occurs due to loss of blood flow to the heart. The condition disrupts individuals’ daily life and limits their performance. Evidence indicates the likely effect of exercise on increasing the capillary density of skeletal muscle and myocardium. Vascular endothelial growth factor (VEGF) and endostatin as well as their common receptors (Flt-۱) are the most important factors involved in angiogenesis. Therefore, this research aimed to evaluate the effect of ۶ weeks of interval training on the VEGF, Flt-۱ and collagen ۱۸ in rats with MI. Methods: ۱۲ male Wistar rats with mean age of ۱۰weeks and average weight of ۲۵۰- ۳۰۰ gr were infected with myocardial infarction and were assigned into two groups of (۱) experimental (۶۰ minutes of interval running on treadmill, each interval ۴ minutes with the ۶۰- ۷۵ percent of Vo۲max and ۲ minutes of active rest at ۵۰- ۶۰ percent of Vo۲max for four days in a week for a period of ۶ weeks) and (۲) control group (without any training). Gene expression was investigated by the PCR technique and Ejection fraction and Shortening fraction were investigated by echocardiograph. Data were analyzed by SPSS ۱۸ using independent samples t-test (p≤۰.۰۵). Results: Results showed that low intensity interval training had a significant effect on increasing the expression level of Flt-۱ (P=۰.۰۲) and VEGF (P=۰.۰۱) genes and no significant change in collagen ۱۸ (P=۰.۳۴). Conclusion: The overall results of the study supported the role of low-intensity interval training in increasing the basic factors affecting the process of angiogenesis after MI.
کلیدواژه ها:
نویسندگان
Mehran Ghahramani
Department of Physical Education, Gilan-E-Gharb, Islamic Azad University, Gilan-E-Gharb,Iran.
Sara Karbalaeifar
Department of Physical Education University of Tehran, Kish International Campus, Kish, Iran.
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