ورود
مقالات فارسیISIکنفرانسهاژورنالها

Interaction of Vitamin D Receptor Gene FokI Variants and Omega-۳ Fatty Acids on Perceived Stress Score and Serum Cortisol Levels in Nurses: A Cross-Sectional Study

محل انتشار: فصلنامه تغذیه و امنیت غذایی، دوره: 9، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 56

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1908098

شناسه ملی سند علمی:

JR_JNFS-9-1_011

تاریخ نمایه سازی: 25 بهمن 1402

چکیده مقاله:

There is a high prevalence of perceived stress among nurses. Recent studies have shown that omega-۳ fatty acids and genetic variants contribute to perceived stress. This study aimed to examine interactions between vitamin D receptor (VDR) gene FokI polymorphism and omega-۳ fatty acids on perceived stress score and serum cortisol levels in nurses. Methods: A total of ۲۶۸ Iranian nurses (۲۴۸ women; ۲۰ men) participated in this cross-sectional study. Omega-۳ fatty acids and perceived stress score of participants were evaluated using a ۳-day food record and the Perceived Stress Scale (PSS)-۱۰, respectively. Serum cortisol concentrations were evaluated by ELISA. VDR FokI polymorphism was genotyped using the restriction fragment length polymorphism method. Results: No significant relationship was found between omega-۳ fatty acids with perceived stress score or cortisol level in FF genotype carriers, but lower intake of PUFA was related to higher cortisol level (P=۰.۰۴) in Ff carriers. Significant interactions were observed between VDR FOKI polymorphism and intakes of eicosapentaenoic acid (EPA) (P Interaction=۰.۰۶), linoleic acid (P Interaction=۰.۰۶), and docosahexaenoic acid (DHA) (P Interaction=۰.۰۶) on serum cortisol, so that lower intake of EPA, linoleic acid, and DHA was associated with an increase in cortisol levels in individuals with ff genotype. Moreover, in carriers of ff genotype, lower intake of EPA was related to the elevated perceived stress score (P Interaction=۰.۰۶). Conclusion: FokI polymorphism interacts with omega-۳ fatty acids (EPA, linoleic acid, and DHA) to increase cortisol level and with EPA to increase perceived stress score in nurses.

کلیدواژه ها:

Fatty acids ، Omega-۳ ، Eicosapentaenoic acid ، Docosahexaenoic acids ، Linoleic acid ، Receptors calcitriol ، Gene-environment interaction

نویسندگان

Zahra Veysi

Department of Community Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Azadeh Dehghani

Department of Community Nutrition, Faculty of Nutrition and Food Science, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Mahnaz Sanjari

Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Zhila Maghbooli

Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

Khadijeh Mirzaei

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Alizadeh S, Djafarian K, Alizadeh H, Mohseni R & Shab-Bidar ...
  • Alizadeh S, et al. ۲۰۱۸. Vitamin D۳ Induces Gene Expression ...
  • Barbadoro P, et al. ۲۰۱۳. Fish oil supplementation reduces cortisol ...
  • Bernburg M, Groneberg DA & Mache S ۲۰۱۹. Mental Health ...
  • Bhatia N, Kishore J, Anand T & Jiloha RC ۲۰۱۰. ...
  • El Ansari W & Berg-Beckhoff G ۲۰۱۵. Nutritional correlates of ...
  • Eyles DW, Smith S, Kinobe R, Hewison M & McGrath ...
  • Fitzgerald JS, Orysiak J, Wilson PB, Mazur-Różycka J & Obminski ...
  • George SA, Khan S, Briggs H & Abelson JL ۲۰۱۰. ...
  • Gheshlagh R, et al. ۲۰۱۷. The prevalence of job stress ...
  • Glocke M, et al. ۲۰۱۳. Impact of vitamin D receptor ...
  • Guilliams TG & Edwards L ۲۰۱۰. Chronic stress and the ...
  • Hamazaki T, Itomura M, Sawazaki S & Nagao Y ۲۰۰۰. ...
  • Harbron J, Van der Merwe L, Zaahl MG, Kotze MJ ...
  • Higbee MR, Chilton JM, El-Saidi M, Duke G & Haas ...
  • Ji LL, et al. ۲۰۱۴. Changes in the expression of ...
  • Junne F, et al. ۲۰۱۷. Determinants of perceived stress in ...
  • Kalueff AV, Lou Y-R, Laaksi I & Tuohimaa P ۲۰۰۴. ...
  • Keenan K, Hipwell AE, Bortner J, Hoffmann A & McAloon ...
  • Kim HS, et al. ۲۰۰۱. Vitamin D receptor polymorphism and ...
  • Kuningas M, et al. ۲۰۰۹. VDR gene variants associate with ...
  • Lange KW ۲۰۲۰. Omega-۳ fatty acids and mental health. Global ...
  • Layé S ۲۰۱۰. Polyunsaturated fatty acids, neuroinflammation and well being. ...
  • Maddahi NS, et al. ۲۰۲۰. Association between dietary energy density ...
  • Maroufizadeh S, Zareiyan A & Sigari N ۲۰۱۴. Reliability and ...
  • Miller AH, Maletic V & Raison CL ۲۰۰۹. Inflammation and ...
  • Rodriguez ACI, et al. ۲۰۱۵. Hypothalamic-pituitary-adrenal axis dysregulation and cortisol ...
  • Rolf L, et al. ۲۰۱۸. Stress-axis regulation by vitamin D۳ ...
  • Takeuchi T, Iwanaga M & Harada E ۲۰۰۳. Possible regulatory ...
  • Taylor AM & Holscher HD ۲۰۲۰. A review of dietary ...
  • Walvekar SS, Ambekar JG & Devaranavadagi BB ۲۰۱۵. Study on ...
  • Wingenfeld K, et al. ۲۰۱۷. Stress reactivity and its effects ...
  • Yalamanchili V & Gallagher JC ۲۰۱۲. Treatment with hormone therapy ...
  • Gheshlagh R, Parizad N, Dalvand S, Zarei M, Farajzadeh M, ...
  • Maddahi NS, Yarizadeh H, Setayesh L, Nasir Y, Alizadeh S, ...
    • نمایش کامل مراجع