Total Antioxidant Capacity, Lipid Peroxidation, Thiol Group and Catalase Activity in Patients With Kidney Stone

Background: Urinary tract stones are one of the most common causes of kidney disease. There is evidence for the possible involvement of oxidative stress in the formation of kidney stones and renal cell injury. Objectives: In this study, we aimed to determine the total antioxidant capacity (TAC), malondialdehyde (MDA), serum thiol group, ceruloplasmin (CP) levels and catalase (CAT) activity in the serum of the patients with kidney stones. Materials and Methods: This study was conducted as a case-control study. A total of ۳۱ patients (۱۶ males and ۱۵ females) with kidney stone(s) and a comparative normal control group including ۲۱ (۱۲ males and ۹ females) healthy subjects were included. Results: The present study revealed that TAC level was significantly higher in the control group (P=۰.۰۰۴), and the mean thiol group was remarkably decreased in the patient group (P<۰.۰۰۱). Moreover, CAT activity decreased in the patients but it was not significant (P=۰.۲۳). On the other hand, the findings showed that the serum CP level significantly increased in the patient group (P<۰.۰۰۱). MDA level also increased in the patient group, although this increment was not significant (P=۰.۸۷). Conclusions: It can be concluded that the reduction of antioxidant indices in the patients with kidney stones can damage the renal tubular cells and strengthen the accumulation of crystals and the formation of kidney stones.