Virucidal potential of Prosopis spicigera and Mangifera indica on human peripheral blood mononuclear cells

Introduction: The treatment of viral infections with the available antiviral drugs is not free of side effects. Therefore, in the present study, our group focused on antiviral activity against Newcastle disease (NDV) and IBD viruses using medicinal plants especially leaves of Prosopis spicigera and Mangifera indica.Methods: Different medicinal plant products especially leaves of P. spicigera and M. indica were tested in the form of aqueous leaves extracts (۰.۵- ۳۰ mg/mL; ۵۰ μL) for anti-microbial activities on human peripheral blood mononuclear cells (PBMC) pertaining to determine their proliferation rate (cytotoxicity assay), tumor necrosis factor alpha (TNFα) production and CD۱۴ monocyte surface marker.Results: Three medicinal plant aqueous extracts showed significant antimicrobial activity against PBMC at higher doses with respect to decline in proliferation assay, TNFα production and CD۱۴ monocyte surface marker as compared to control.Conclusion: Aqueous leaves extract of P. spicigera and M. indica showed antimicrobial activities and might be useful for the treatment of various viral diseases.