Comparison of HBV-DNA Levels with Biochemical and Microbiological Parameters for Chronic Hepatitis Evaluation, Bursa, Turkey

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 45

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شناسه ملی سند علمی:

JR_JMMI-9-1_004

تاریخ نمایه سازی: 29 بهمن 1402

چکیده مقاله:

Introduction: HBV-DNA levels are used to diagnose chronic hepatitis B (CHB) disease, determine the infection phase, decide on the treatment, and determine the disease course. We aimed to compare the microbiological and biochemical parameters of patients followed up with chronic hepatitis B pre-diagnosis in our hospital according to their HBV-DNA levels. Methods: HBV-DNA levels were analyzed with the Real-Time PCR method in blood samples of ۵۰۰ pre-diagnosed CHB patients between February-June ۲۰۱۸, retrospectively. The biochemical parameters of the patients were measured by an automatic biochemical immunoassay analyzer (Beckman Coulter DXI ۸۰۰, USA), and the microbiological parameters of patients were determined by an automatic analyzer (Roche Cobas ۶۰۰۰, Germany). The differences between the values of biochemical and microbiological parameters of patients were determined according to HBV-DNA. Results: Mean corpuscular volume (MCV) was higher in patients with hepatitis B virus-DNA (HBV-DNA)>۲۰۰۰۰ IU/mL than patients with negative HBV-DNA, HBV-DNA<۲۰۰۰ IU/mL, and HBV-DNA ۲۰۰۰-۲۰۰۰۰ IU/mL (P<۰.۰۵, P<۰.۰۱, P<۰.۰۱). Gamma-glutamyl transpeptidase (GGT) was lower in patients with HBV-DNA ranging from ۲۰۰۰-۲۰۰۰۰ IU/mL than HBV-DNA negative patients, HBV-DNA<۲۰۰۰ IU/mL and HBV-DNA>۲۰۰۰۰ IU/mL (P<۰.۰۵). Albumin was lower in patients with  HBV-DNA>۲۰۰۰۰ IU/mL than patients with HBV-DNA ۲۰۰۰-۲۰۰۰۰ IU/mL and HBV-DNA<۲۰۰۰ IU/mL (P<۰.۰۱). Hepatitis B surface antigen (HBsAg) levels were higher in patients with HBV-DNA ۲۰۰۰-۲۰۰۰۰ IU/mL than HBV-DNA negative patients, and patients with HBV-DNA<۲۰۰۰ IU/mL and HBV-DNA>۲۰۰۰۰ IU/mL (P<۰.۰۵, P<۰.۰۵, P<۰.۰۵). Albumin was individually correlated with the HBV-DNA by ۲.۹%, negatively (P<۰.۰۱). Conclusion: MCV, GGT, albumin, HBsAg levels might be used as indicators to diagnose CHB disease, establish the infection phase, decide the treatment, and determine the course of the disease together with HBV-DNA levels.

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نویسندگان

Sanem Karadag Gecgel

University of Health Sciences, Bursa Yuksek Ihtisas Training and Reseach Hospital

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