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مقالات فارسیISIکنفرانسهاژورنالها

Prevalence and Risk Factors of Pulmonary Fungal Pathogens among Symptomatic Patients with or without Tuberculosis at Gombe, Nigeria

محل انتشار: مجله میکروبیولوژی پزشکی و بیماریهای عفونی، دوره: 8، شماره: 3
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 44

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1917649

شناسه ملی سند علمی:

JR_JMMI-8-3_001

تاریخ نمایه سازی: 29 بهمن 1402

چکیده مقاله:

Introduction: Pulmonary fungal infections are a significant etiology of morbidity among immunocompromised and immunosuppressed patients. This study aimed to determine the prevalence of fungal pathogens and associated risk factors among pulmonary tuberculosis (PTB) and non-PTB patients attending Federal Teaching Hospital, Gombe, Nigeria. Methods: Three consecutive early morning sputum samples were collected from ۴۳ PTB patients and ۱۷۳ non-PTB persons and then examined for fungal pathogens using standard mycological stains, microscopy, and biochemical assays. All the participants were screened for HIV by the World Health Organization HIV testing algorithm and M. tuberculosis infection using GeneXpert ® nested PCR equipment. Samples with at least two significant fungal growths were considered positive. Results: Out of ۲۱۶ sputa, ۷۳.۶% showed fungal growth in cultures. One hundred percent and ۶۷% of PTB and non-PTB participants had positive sputa culture, respectively. In PTB patients, Candida albicans (۲۵.۶%) and Aspergillus fumigatus (۲۰.۹%), and in non-PTB individuals A. fumigatus (۵۱.۷%) and A. nigar (۱۷.۲%) were the most prevalent species. Age and residential areas were significantly associated with fungal infection in PTB and non-PTB subjects (p˂۰.۰۵). Cigarette smoking, prolonged antibiotic use, and having domestic pets were significant risk factors for developing pulmonary fungal infections in both groups (p˂۰.۰۵). None of the studied risk factors was significantly associated with pulmonary mycosis among TB patients (p˃۰.۰۵). However, prolonged use of antibiotics was a significant risk factor of pulmonary fungal infection among non-TB patients (p=۰.۰۰۹). Conclusion: Our study showed that PTB was a predisposing factor for fungal infection, especially among individuals with low socioeconomic status.

کلیدواژه ها:

Pulmonary Symptoms ، Risk factors ، Fungal Infection ، Mycosis ، Tuberculosis coinfection

نویسندگان

Fatima Muhammad Sani

Department of Biological Sciences, Abubakar Tafawa Balewa University, Bauchi, Nigeria

Idris Nasir Abdullahi

Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria

Olawale Sunday Animasaun

Nigeria Field Epidemiology and Laboratory Training Program, African Field Epidemiology Network, Abuja, Nigeria

Peter Elisha Ghamba

WHO National Polio Laboratory, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria

Abubakar Umar Anka

Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria

Matthew Oluwafemi Salami

Department of Medical Microbiology, Federal School of Medical Laboratory Science, Jos, Nigeria

Amos Dangana

Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja Nigeria

Dele Ohinoyi Amadu

Department of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria

Ahaneku Iherue Osuji

Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja Nigeria

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