Antibacterial and Antifungal Activities of Different Lichens Extracts
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 36
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شناسه ملی سند علمی:
JR_JMMI-2-2_006
تاریخ نمایه سازی: 29 بهمن 1402
چکیده مقاله:
Introduction: Natural products have been the most successful source of potential drug leads. One of them is lichens, which have been used since antiquity as natural sources of drugs. The aim of this study was to investigate the antibacterial and antifungal activity of different extracts of the Iranian lichens in Ilam Province. Methods: The aqueous, acetone, and methanol extracts of ۶ lichen species, including Caloplaca variabilis, Fulgensia subbracteata, Lecanora muralis, Physcia adscendens, Psora decipiens, and Megaspora verrucosa, were produced using Soxhlet extractor. Then, antibacterial and antifungal activities of them against ۶ standard strains of bacteria, including Enterococcus faecalis ATCC ۲۳۲۱, Escherichia coli ATCC ۱۶۵۲, Proteus mirabilis ATCC ۲۶۰۱, Salmonella typhi ATCC ۱۶۷۹, Staphylococcus aureus ATCC ۱۸۸۵, and Staphylococcus epidermidis ATCC ۲۴۰۵ and two fungi, including Fusarium moniliforme and Verticillium dahliae, were evaluated using the disc-diffusion method and the minimal inhibitory concentration was determined by broth tube dilution. Streptomycin (۱۰ µg/ml) and ketoconazole (۱۰ µg/ml) were used as positive controls for bacteria and fungi, respectively. Sterile distilled dimethyl sulfoxide (DMSO) was used as negative control. Results: Methanol extract from F. subbracteata and L. muralis lichens showed relatively high antibacterial activities (p<۰.۰۱), whereas aqueous extracts showed no activity against the microorganisms and only acetone extract of L. muralis showed antibacterial activity against the S. epidermidis (MIC=۵۰۰). Methanol extracts of F. subbracteata and L. muralis had higher antifungal activities than others. Conclusion: The methanol extracts of L. muralis and F. subbracteata showed the highest activity against the bacteria and fungi and it seems that they have some antibacterial and antifungal properties.
کلیدواژه ها:
نویسندگان
Tahereh Valadbeigi
Department of Plant Microbiology, Ilam Universty, Ilam, Iran
Ali Mohammad Bahrami
Department of Pathology, Facuty of Para Veterinary Medicine, Ilam University, Ilam, Iran
Minoo Shaddel
Department of Parasitology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
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